Prognostic value of ground glass opacity on computed tomography in pathological stage I pulmonary adenocarcinoma: A meta-analysis

Table 1 Basic characteristics of included studies

Ref.	Country	Sample size	GGO ratio	TNM	NOS	Endpoint
Takamochi et al[18], 2004	Japan	189	0.8	IA + IB	7	OS
Nakayama et al[19], 2010	Japan	201	0.5	IA	6	DFS
Yanagawa et al[20], 2014	Japan	145	0.37	IA + IB	7	OS, DFS
Nakamura et al[21], 2015	Japan	113	0.5	IB	7	OS, DFS
Wang et al[22], 2016	United States	79	0	IA + IB	6	OS
Zhong et al[23], 2018	Japan	354	0.5	IA	7	DFS
Miyoshi et al[25], 2019	Japan	809	0	IA	7	OS
Kinoshita et al[24], 2019	Japan	274	0	IA + IB	8	DFS
Zhong et al[28], 2021	China	620	0	IA + IB	6	OS, DFS
Han et al[26], 2020	Korea	544	0.5	IA	8	DFS
Phillips et al[27], 2020	United States	357	0	IA	7	OS, DFS
Shigefuku et al[29], 2021	Japan	782	0	IA + IB	7	OS

GGO: Ground glass opacity; TNM: Tumor-node-metastasis; NOS: Newcastle-Ottawa quality assessment scale; OS: Overall survival; DFS: Disease-free survival.

Table 2 Results of meta-analysis

	No. studies	HR	95%CI	P value	I2 (%)	P value
Overall survival	8 [18,20-23,27-29]	0.44	0.34-0.59	< 0.001	24.3	0.236
> 01	3 [18,20,21]	0.14	0.05-0.36	< 0.001	0.0	0.943
01	5 [22,23,27-29]	0.49	0.37-0.66	< 0.001	0.0	0.583
Disease-free survival	8 [19-21,23,24,26-28]	0.35	0.18-0.70	0.003	88.2	< 0.001
> 01	5 [19-21,23,26]	0.29	0.10-0.87	0.027	89.1	< 0.001
01	3 [24,27,28]	0.42	0.23-0.75	0.004	49.8	0.136

¹Subgroup analysis was conducted based on the cutoff values of ground glass opacity proportion.

HR: Hazard ratio; CI: Confidence interval.