Pan XL, Liao ZL, Yao H, Yan WJ, Wen DY, Wang Y, Li ZL. Prognostic value of ground glass opacity on computed tomography in pathological stage I pulmonary adenocarcinoma: A meta-analysis. World J Clin Cases 2021; 9(33): 10222-10232 [PMID: 34904092 DOI: 10.12998/wjcc.v9.i33.10222]
Corresponding Author of This Article
Zhen-Lin Li, MD, Professor, Department of Radiology, West China Hospital, Sichuan University, No. 37 Guoxuexiang, Chengdu 610041, Sichuan Province, China. 17380096151@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 26, 2021; 9(33): 10222-10232 Published online Nov 26, 2021. doi: 10.12998/wjcc.v9.i33.10222
Prognostic value of ground glass opacity on computed tomography in pathological stage I pulmonary adenocarcinoma: A meta-analysis
Xue-Lin Pan, Zi-Ling Liao, Hui Yao, Wei-Jie Yan, De-Ying Wen, Yan Wang, Zhen-Lin Li
Xue-Lin Pan, Zi-Ling Liao, Hui Yao, Wei-Jie Yan, De-Ying Wen, Zhen-Lin Li, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Yan Wang, Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Li ZL and Wang Y designed the research; Pan XL, Liao ZL and Yao H conducted the literature search and collected and retrieved the data; Yan WJ, Wen DY and Wang Y analyzed the data; Pan XL wrote and revised the manuscript; All authors approved the final version.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
PRISMA 2009 Checklist statement: This meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA 2020) checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen-Lin Li, MD, Professor, Department of Radiology, West China Hospital, Sichuan University, No. 37 Guoxuexiang, Chengdu 610041, Sichuan Province, China. 17380096151@163.com
Received: July 7, 2021 Peer-review started: July 7, 2021 First decision: August 18, 2021 Revised: August 18, 2021 Accepted: September 10, 2021 Article in press: September 10, 2021 Published online: November 26, 2021
ARTICLE HIGHLIGHTS
Research background
The presence of ground glass opacity (GGO) in lung adenocarcinoma usually indicates the indolent nature of lesions, and the proportion of GGO reflects the malignant degree of pulmonary adenocarcinoma to a certain extent
Research motivation
The prognostic role of GGO on computed tomography (CT) in stage I pulmonary adenocarcinoma patients remains unclear now.
Research objectives
To identify the prognostic value of GGO on CT in lung adenocarcinoma patients who were pathologically diagnosed with tumor-node-metastasis stage I.
Research methods
Several databases were searched for relevant studies. The hazard ratio and corresponding 95% confidence interval were combined to assess the association between the presence of GGO and prognosis, representing as the overall survival and disease-free survival. Subgroup analysis based on the ratio of GGO was also conducted.
Research results
GGO predicted favorable overall survival (P < 0.001) and disease-free survival (P = 0.003). Subgroup analysis based on the ratio of GGO further demonstrated that the proportion of GGO was a good prognostic indicator in pathological stage I pulmonary adenocarcinoma patients, and patients with a higher ratio of GGO showed better prognosis than patients with a lower GGO ratio did.
Research conclusions
The presence of GGO on CT predicted favorable prognosis in tumor-node-metastasis stage I lung adenocarcinoma.
Research perspectives
Patients with a higher GGO ratio were more likely to have a better prognosis than patients with a lower GGO ratio.
