Systemic immune inflammation index, ratio of lymphocytes to monocytes, lactate dehydrogenase and prognosis of diffuse large B-cell lymphoma patients

Table 1 The comparison of systemic immune inflammation index in patients with different clinicopathological features

Clinicopathological features	n	SII (%)	t	P value
Sex			-0.321	0.749
Male	40	519.29 ± 98.29
Female	28	526.84 ± 91.10
Age (yr)			-0.137	0.891
< 60	22	520.02 ± 94.50
≥ 60	46	523.54 ± 101.10
Ann Arbor stage			-2.377	0.020
I-II	41	501.22 ± 85.50
III-IV	27	554.56 ± 97.83
ECOG scores			-2.906	0.005
< 2	46	498.82 ± 95.30
≥ 2	22	571.70 ± 99.82
IPI scores			-1.378	0.173
0-1	36	506.60 ± 101.02
2-5	32	540.07 ± 98.82
Hans			-0.445	0.658
GCB	26	515.58 ± 100.43
Non GCB	42	526.62 ± 98.85
BCL2 expression			0.790	0.432
< 50%	40	530.03 ± 93.04
≥ 50%	28	511.50 ± 98.20
Ki-67			-0.402	0.689
< 70%	23	515.53 ± 99.40
≥ 70%	45	525.91 ± 101.43

SII: Systemic immune inflammation index; IPI: International prognostic index; ECOG: Eastern Cooperative Oncology Group; GCB: Germinal center B-cell.

Table 2 The comparison of ratio of lymphocytes to monocytes in patients with different clinicopathological features

Clinicopathological features	LMR	t	P value
Sex		-0.976	0.333
Male	2.61 ± 0.45
Female	2.74 ± 0.65
Age (yr)		0.283	0.778
< 60 year	2.70 ± 0.49
≥ 60 year	2.66 ± 0.57
Ann Arbor stage		-4.559	< 0.001
I-II	2.41 ± 0.52
III-IV	3.06 ± 0.64
ECOG scores		-3.280	0.002
< 2	2.52 ± 0.50
≥ 2	2.98 ± 0.62
IPI scores		-2.339	0.022
0-1	2.54 ± 0.52
2-5	2.82 ± 0.46
Hans		-0.338	0.737
GCB	2.64 ± 0.43
Non GCB	2.68 ± 0.50
BCL2 expression		-0.173	0.863
< 50%	2.66 ± 0.44
≥ 50%	2.68 ± 0.51
Ki-67		0.442	0.660
< 70%	2.71 ± 0.55
≥ 70%	2.65 ± 0.52

LMR: Ratio of lymphocytes to monocytes; IPI: International prognostic index; ECOG: Eastern Cooperative Oncology Group; GCB: Germinal center B-cell.

Table 3 The comparison of ratio of lymphocytes to monocytes to lactate dehydrogenase in patients with different clinicopathological features

Clinicopathological features	LMR/LDH	t	P value
Sex		-1.947	0.056
Male	0.38 ± 0.10
Female	0.43 ± 0.11
Age (yr)		0.796	0.429
< 60	0.41 ± 0.09
≥ 60	0.39 ± 0.10
Ann Arbor stage		-4.799	< 0.001
I-II	0.36 ± 0.08
III-IV	0.46 ± 0.09
ECOG scores		-5.977	< .001
< 2	0.35 ± 0.09
≥ 2	0.50 ± 0.11
IPI scores		-4.366	< 0.001
0-1	0.36 ± 0.08
2-5	0.45 ± 0.09
Hans		0.853	0.397
GCB	0.41 ± 0.10
Non GCB	0.39 ± 0.09
BCL2 expression		-0.964	0.339
< 50%	0.39 ± 0.08
≥ 50%	0.41 ± 0.09
Ki-67		0.835	0.407
< 70%	0.41 ± 0.10
≥ 70%	0.39 ± 0.09

LMR: Ratio of lymphocytes to monocytes; LDH: Lactate dehydrogenase; IPI: International prognostic index; ECOG: Eastern Cooperative Oncology Group; GCB: Germinal center B-cell.

Table 4 The progression-free survival times of patients with different systemic immune inflammation index, ratio of lymphocytes to monocytes and ratio of lymphocytes to monocytes to lactate dehydrogenase expression

Groups	Median progression free survival time	95%CI	χ2	P value
SII high expression	34 mo	32.52-38.50	7.742	0.222
SII low expression	42 mo	39.50-46.16
LMR high expression	35 mo	33.42-36.58	8.356	0.004
LMR low expression	43 mo	40.64-45.36
LMR/LDH high expression	35 mo	33.49-36.51	15.163	0.000
LMR/LDH low expression	43 mo	40.73-45.27

SII: Systemic immune inflammation index; LMR: Ratio of lymphocytes to monocytes; LDH: Lactate dehydrogenase.

Table 5 Correlation analysis

Index	SII	LMR	LMR/LDH
SII	-	0.451a	0.322a
LMR	0.451a	-	0.511a
LMR/LDH	0.322a	0.511a	-

^aP < 0.05 between the groups. SII: Systemic immune inflammation index; LMR: Ratio of lymphocytes to monocytes; LDH: Lactate dehydrogenase.

Table 6 Cox proportional risk regression results

Index	HR (95%CI)	P value
Sex	0.882 (0.810-1.102)	0.443
Age	1.343 (1.102-1.928)	0.021
Ann Arbor stage	1.892 (1.303-2.811)	0.004
ECOG scores	1.783 (1.232-2.704)	0.014
IPI scores	1.903 (1.454-2.554)	0.009
Hans	0.928 (0.783-1.432)	0.323
BCL2 expression	0.782 (0.662-1.044)	0.314
Ki-67	1.102 (0.922-1.782)	0.401
SII	1.143 (1.044-1.604)	0.020
LMR	1.665 (1.182-2.433)	0.006
LMR/LDH	1.704 (1.115-2.302)	0.004

IPI: International prognostic index; ECOG: Eastern Cooperative Oncology Group; GCB: Germinal center B-cell; SII: Systemic immune inflammation index; LMR: Ratio of lymphocytes to monocytes; LDH: Lactate dehydrogenase.