Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 16, 2021; 9(32): 9825-9834
Published online Nov 16, 2021. doi: 10.12998/wjcc.v9.i32.9825
Systemic immune inflammation index, ratio of lymphocytes to monocytes, lactate dehydrogenase and prognosis of diffuse large B-cell lymphoma patients
Xiao-Bo Wu, Shu-Ling Hou, Hu Liu
Xiao-Bo Wu, Shu-Ling Hou, Hu Liu, Department of Lymphoma, Cancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan 030032, Shanxi Province, China
Xiao-Bo Wu, Shu-Ling Hou, Hu Liu, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Author contributions: Wu XB designed the research study; Hou SL performed the research; Liu Hu contributed new reagents and analytic tools; Wu XB analyzed the data and wrote the manuscript; and all authors have read and approve the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Institutional Review Board.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: No conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Bo Wu, MMed, Attending Doctor, Department of Lymphoma, Cancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, No. 99 Longcheng Street, Taiyuan 030032, Shanxi Province, China. maviswxb@163.com
Received: August 18, 2021
Peer-review started: August 18, 2021
First decision: September 29, 2021
Revised: October 8, 2021
Accepted: October 25, 2021
Article in press: October 25, 2021
Published online: November 16, 2021
Processing time: 83 Days and 13.6 Hours
ARTICLE HIGHLIGHTS
Research background

Diffuse large B-cell lymphoma (DLBCL), the most common malignant proliferative disease of the lymphatic system, is commonly associated with inflammation.

Research motivation

It is still necessary to find effective biomarkers to predict the prognosis and recurrence of DLBCL among patients.

Research objectives

We discussed the association between the systemic immune inflammation index (SII), ratio of lymphocytes to monocytes (LMR), ratio of LMR to lactate dehydrogenase (LDH), and prognosis of DLBCL patients.

Research methods

Total 68 patients with diffuse large B-cell lymphoma selected for treatment in our hospital. The differences in the SII, LMR, and LMR/LDH among patients with different clinicopathological features were analyzed.

Research results

SII, LMR, and LMR/LDH were influencing factors for the prognosis of DLBCL patients.

Research conclusions

The SII, LMR, and LMR/LDH in DLBCL patients were related to the clinicopathological features of the patients to a certain extent and were also influencing factors for the prognosis of DLBCL patients.

Research perspectives

It is necessary to perform larger studies to help clinicians choose a reasonable therapeutic regimen.