Colorectal cancer patients in a tertiary hospital in Indonesia: Prevalence of the younger population and associated factors

Table 1 Demographics of colorectal cancer patients in 2008-2019

Variables	< 50-years-old, n (%)	≥ 50-years-old, n (%)	Total subjects, n (%)
Study population			495 (100)
Age at diagnosis
< 50-years-old	205 (41.4)
8-29	26 (5.3)
30-39	62 (12.5)
40-49	117 (23.6)
≥ 50-years-old		290 (58.6)
50-59		135 (27.3)
60-69		95 (19.2)
70-79		52 (10.5)
80-89		8 (1.6)
Sex
Male	110 (53.7)	162 (55.9)	272 (54.9)
Female	95 (46.3)	128 (44.1)	223 (45.1)
Time period
2008-2013	47 (41.2)	67 (58.8)	114 (23.0)
2014-2019	158 (41.5)	223 (58.5)	381 (76.9)

Table 2 Histopathological features of early-onset and late-onset colorectal cancer patients in 2008-2019

Histopathological feature	< 50-years-old, n (%)	≥ 50-years-old, n (%)	Total, n (%)
Adenocarcinoma	184 (89.8)	273 (94.1)	457 (92.3)
Nonepithelial	6 (6.9)	25 (6.1)	31 (6.3)
Carcinoid	3 (3.4)	4 (1.0)	7 (1.4)

Table 3 Anatomical sites of tumors presenting in early- and late-onset colorectal cancer patients in 2008-2019

Tumor sites	< 50-years-old, n (%)	≥ 50-years-old, n (%)	Total, n (%)
Right side	45 (22.0)	67 (23.1)	112 (22.6)
Cecum	13 (6.3)	17 (5.9)	30 (6.1)
Ascending colon	27 (13.2)	34 (11.7)	61 (12.3)
Hepatic flexure	1 (1.1)	5 (1.2)	6 (1.2)
Transverse colon	4 (2.0)	11 (3.8)	15 (3.0)
Left side	160 (78.0)	223 (76.9)	383 (77.4)
Descending colon	17 (8.3)	9 (3.1)	26 (5.3)
Rectum	84 (41.0)	132 (45.5)	216 (43.6)
Sigmoid	13 (6.3)	42 (14.5)	55 (11.1)
Rectosigmoid	36 (17.6)	38 (13.1)	74 (14.9)
Anus	1 (1.1)	1 (0.2)	2 (0.4)
Anorectal	9 (4.4)	1 (0.3)	10 (2.0)

Table 4 Clinical manifestations of early- and late-onset colorectal cancer patients in 2008-2019

Clinical manifestation	< 50-years-old, n (%)	≥ 50-years-old, n (%)	Total, n (%)	P
Diarrhea	46 (22.4)	83 (28.6)	129 (26.1)	0.123
Constipation	69 (33.7)	94 (32.4)	163 (32.9)	0.772
Abdominal paina	114 (55.6)	127 (43.8)	241 (48.7)	0.011
Hematochezia	99 (48.3)	150 (51.7)	249 (50.3)	0.452
Weight loss	72 (35.1)	97 (33.4)	169 (34.1)	0.699

^aFisher’s exact test, P < 0.05.

Table 5 Clinical manifestations of early- and late-onset colorectal cancer patients in 2008-2019

Variables	< 50-years-old, n (%)	≥ 50-years-old, n (%)	Total, n (%)	P
Smoking	69 (33.7)	114 (39.3)	183 (37)	0.199
Parental history of CRC	8 (3.9)	4 (1.4)	12 (2.4)	0.072
Other family history of CRC	6 (2.9)	8 (2.8)	14 (2.8)	0.911
Suspicion of FAP	4 (2.0)	6 (2.1)	10 (2.0)	0.927
Suspicion of HNPCCa	19 (9.3)	12 (4.1)	31 (6.3)	< 0.05
BMI
Underweightc	71 (34.6)	58 (20.0)	129 (26.1)	< 0.001
Normoweight	71 (34.6)	101 (34.8)	172 (34.7)	0.521
Overweight and obeseb	63 (30.7)	131 (45.2)	194 (39.2)	< 0.005
Comorbidities
Diabetes mellitusc	8 (3.9)	53 (18.3)	61 (12.3)	< 0.001
Hypertensionc	7 (3.4)	73 (25.2)	80 (16.2)	< 0.001

^aChi-square test, P < 0.05.

^bFisher’s exact test, P < 0.005.

^cFisher’s exact test, P < 0.001.

BMI: Body mass index; CRC: Colorectal cancer; FAP: Familial adenomatous polyposis; HNPCC: Hereditary nonpolyposis colorectal cancer.