Retrospective Study
Copyright ©The Author(s) 2021.
World J Clin Cases. Nov 16, 2021; 9(32): 9792-9803
Published online Nov 16, 2021. doi: 10.12998/wjcc.v9.i32.9792
Table 1 Baseline and clinical characteristics

Mutant EGFR group (n = 31)
Wild-type group (n = 67)
P value
Age (yr)66.6 ± 14.262.7 ± 15.60.221
< 6013 (41.9%)37 (55.2%)
≥ 6018 (58.1%)30 (44.8%)
Male12 (38.7%)30 (44.8%)0.573
Smoking history8 (25.8%)24 (35.8%)0.326
Nodule property0.372
Pure GGNs7 (22.6%)21 (31.3%)
Partial solid nodules24 (77.4%)46 (68.7%)
Histopathologic diagnosis0.723
Preinvasive lesions (AAH + AIS)5 (16.1%)9 (13.4%)
Invasive lesions (MIA + IPA)26 (83.9%)58 (86.6%)
Position of the nodule0.471
Right upper lobe10 (32.3%)27 (40.3%)
Right middle lobe4 (12.9%)8 (11.9%)
Right lower lobe6 (19.4%)9 (13.4%)
Left upper lobe5 (16.1%)17 (25.4%)
Left lower lobe6 (19.4%)6 (9.0%)
Time between CT scan and surgery (days)7.0 (4.5, 13.5)8.0 (6.0, 13.0)0.545
Table 2 High-resolution computerized tomography signs
HRCT findings
Mutant EGFR group (n = 31)
Wild-type group (n = 67)
P value
Nodule size (mm)17.19 ± 6.7914.37 ± 6.300.047a
Pure GGNs
Nodule size (mm)12.79 ± 5.249.24 ± 3.260.042a
Partial solid nodules
Nodule size (mm)18.63 ± 6.4716.68 ± 6.050.216
Proportion of ground-glass component (%)56.10 ± 24.0151.05 ± 28.130.457
Nodule morphology0.137
Round-like/ovoid14 (45.2%)41 (61.2%)
Irregular17 (54.8%)26 (38.8%)
Spicules on the edge of the nodule20 (64.5%)34 (50.7%)0.202
Lobules on the border of the nodule29 (93.5%)61 (91.0%)1.000
Vacuole/honeycomb sign25 (80.6%)36 (53.7%)0.011a
Pleural indentation20 (64.5%)33 (49.3%)0.159
Relationship with bronchus/bronchovascular bundles0.613
Bronchus truncated in the nodule1 (3.2%)6 (9.0%)
Bronchus continuous in the nodule, with dilation or twisted appearance11 (35.5%)20 (29.9%)
Bronchus continuous in the nodule, without dilation or twisted appearance7 (22.6%)11 (16.4%)
Bronchus not associated with ground-glass shadows12 (38.7%)30 (44.8%)
Relationship with blood vessels0.488
Blood vessels closely packed around the nodule with adherent-like pattern0 (0.0%)3 (4.5%)
Blood vessels closely packed within the nodule20 (64.5%)41 (61.2%)
Vascular clustering around the nodule11 (35.5%)23 (34.3%)
Table 3 Logistic regression analysis for the presence of epidermal growth factor receptor mutations
VariablesOR95%CIP value
Nodule size1.0681.000-1.1410.049a
Nodule size + vacuole/honeycomb sign1.1201.023-1.2270.014a
Table 4 Area under the receiver operating characteristic curve of the models
Model
AUC
SE
95%CI
P value
Nodule size0.6250.0610.504–0.7450.048a
Nodule size + vacuole/honeycomb sign0.6980.0550.589–0.8060.002a