Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 16, 2021; 9(32): 9792-9803
Published online Nov 16, 2021. doi: 10.12998/wjcc.v9.i32.9792
High-resolution computed tomography findings independently predict epidermal growth factor receptor mutation status in ground-glass nodular lung adenocarcinoma
Ping Zhu, Xiao-Jun Xu, Min-Ming Zhang, Shu-Feng Fan
Ping Zhu, Xiao-Jun Xu, Min-Ming Zhang, Shu-Feng Fan, Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China
Author contributions: Zhu P contributed to literature research, clinical studies, statistical analysis, manuscript preparation and editing; Xu XJ contributed to experimental studies/data analysis; Zhang MM was the guarantor of integrity of the entire study; Fan SF contributed to study concepts and design; all authors have read and approved the final manuscript.
Supported by the Zhejiang Province Traditional Chinese Medicine Science and Technology Plan - Zhejiang Province Traditional Chinese Medicine Project for Traditional Chinese Medicine Scientific Research (2020) (Class B), No. 2020ZB117.
Institutional review board statement: This study was approved by the Ethics Committee of the Second Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Province, China.
Informed consent statement: The individual consent was waived by the committee owing to the retrospective study design.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: The data set supporting the results of this article are included within the article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Feng Fan, PhD, Doctor, Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, No. 318 Chaowang Road, Gongshu District, Hangzhou 310005, Zhejiang Province, China. shufengfan16@126.com
Received: June 4, 2021
Peer-review started: June 4, 2021
First decision: June 25, 2021
Revised: July 30, 2021
Accepted: September 22, 2021
Article in press: September 22, 2021
Published online: November 16, 2021
Processing time: 158 Days and 16.3 Hours
Core Tip

Core Tip: For patients who have been clinically diagnosed with lung adenocarcinoma but failed to undergo epidermal growth factor receptor (EGFR) gene testing: When the lesion is shown as a pure ground glass nodule, and the size of the nodule is ≥ 8.65 mm, it can be used as an independent indicator to predict EGFR gene mutation. The appearance of the vesicle sign or honeycomb sign may indicate a mutation in the EGFR gene.