Effects on newborns of applying bupivacaine combined with different doses of fentanyl for cesarean section

Table 1 Comparison of general data in the four groups of patients (n = 30, mean ± SD)

	B	BF10	BF30	BF50
Age	28.9 ± 4.3	29.1 ± 3.0	28.0 ± 2.8	28.3 ± 2.4
Weight (kg)	75.1 ± 3.9	74.1 ± 6.6	73.6 ± 3.8	74.1 ± 4.4
Height (cm)	163.7 ± 4.2	162.2 ± 3.7	163.3 ± 2.7	162.8 ± 2.5
Gestational age (wk)	38.4 ± 1.3	38.4 ± 1.3	38.6 ± 0.8	38.7 ± 0.9
ASA grade (I/II)	22/8	23/7	22/8	23/7
MAP (mmHg)	91.6 ± 7.3	90.0 ± 7.1	93.0 ± 9.6	89.7 ± 7.1
Heart rate	89.0 ± 15.2	89.8 ± 14.1	92.8 ± 20.3	93.5 ± 10.4

Group B (bupivacaine group), BF10 group (bupivacaine combined with 10 μg fentanyl), BF30 group (bupivacaine combined with 30 μg fentanyl), BF50 group (bupivacaine combined with 50 μg fentanyl). MAP: Mean arterial pressure.

Table 2 Comparison of the results of related indices of anesthesia and surgery in the four groups of patients (n = 30, mean ± SD)

	B	BF10	BF30	BF50
3 min MAP decreased after anesthesia (as a percentage of the basal value) %	11.5	10.9	7.6	8.6
The time of sensory block reaching T6 (min)	4.13 ± 0.74	3.23 ± 0.48	3.24 ± 0.40	3.22 ± 0.56
The time when movement was completely blocked (min)	9.85 ± 1.34	8.10 ± 1.15	7.70 ± 0.92	7.80 ± 1.24
Time from completion of anesthesia to cesarean section (min)	13.75 ± 1.20	13.60 ± 1.44	13.96 ± 1.48	13.72 ± 1.31
Duration of operation (min)	59.40 ± 7.33	60.75 ± 4.56	59.28 ± 4.22	61.30 ± 6.36
Sensory block recovery time (min)	254.95 ± 23.32	301.10 ± 18.75	322.75 ± 22.21	373.15 ± 20.74

Group B (bupivacaine group), BF10 group (bupivacaine combined with 10 μg fentanyl), BF30 group (bupivacaine combined with 30 μg fentanyl), BF50 group (bupivacaine combined with 50 μg fentanyl). MAP: Mean arterial pressure.

Table 3 Neonatal umbilical artery blood gas analysis and Apgar score (n = 30, mean ± SD)

	B	BF10	BF30	BF50
pH	7.34 ± 0.04	7.32 ± 0.07	7.33 ± 0.06	7.34 ± 0.04
PO2 (mmHg)	42.3 ± 3.8	43.4 ± 6.0	42.6 ± 3.6	42.8 ± 5.6
PCO2 (mmHg)	31.1 ± 1.7	30.8 ± 2.0	30.9 ± 1.9	30.2 ± 1.8
BE (mEq/L)	-3.1 ± 0.5	-3.2 ± 0.8	-3.3 ± 0.5	-3.1 ± 0.9
Lac (mmol/L)	1.68 ± 0.33	1.68 ± 0.2	1.67 ± 0.25	1.68 ± 0.19
1 min Apgar score ≤ 7(N)	0	0	0	0
5 min Apgar score ≤ 7(N)	0	0	0	0

Group B (bupivacaine group), BF10 group (bupivacaine combined with 10ug fentanyl), BF30 group (bupivacaine combined with 30 μg fentanyl), BF50 group (bupivacaine combined with 50 μg fentanyl).

Table 4 Qualitative detection of fentanyl concentration in umbilical artery blood (OD value) (n = 30, mean ± SD)

OD
BF10	0.139	0.143	0.129	0.136	0.125	0.147	0.141	0.141	0.147	0.132
	0.137	0.138	0.139	0.157	0.150	0.136	0.140	0.146	0.136	0.141
	0.145	0.139	0.139	0.158	0.150	0.136	0.141	0.144	0.161	0.158
BF30	0.132	0.143	0.138	0.160	0.154	0.161	0.143	0.141	0.141	0.137
	0.140	0.152	0.161	0.142	0.142	0.137	0.153	0.152	0.151	0.142
	0.139	0.136	0.138	0.141	0.154	0.148	0.136	0.153	0.139	0.139
BF50	0.138	0.153	0.152	0.151	0.142	0.139	0.136	0.139	0.151	0.154
	0.152	0.152	0.142	0.143	0.141	0.153	0.147	0.155	0.151	0.152
	0.150	0.150	0.152	0.147	0.152	0.150	0.152	0.143	0.151	0.152
Control	0.112