Wang Y, Liu WX, Zhou XH, Yang M, Liu X, Zhang Y, Hai KR, Ye QS. Effects on newborns of applying bupivacaine combined with different doses of fentanyl for cesarean section. World J Clin Cases 2021; 9(23): 6698-6704 [PMID: 34447816 DOI: 10.12998/wjcc.v9.i23.6698]
Corresponding Author of This Article
Qing-Shan Ye, MD, Professor, Department of Anesthesiology, People's Hospital of Ningxia Hui Autonomous Region, No. 301 Zhengyuan North Street, Jinfeng District, Yinchuan 750002, Ningxia Hui Autonomous Region, China. yeqingshan@hotmail.com
Research Domain of This Article
Anesthesiology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 16, 2021; 9(23): 6698-6704 Published online Aug 16, 2021. doi: 10.12998/wjcc.v9.i23.6698
Effects on newborns of applying bupivacaine combined with different doses of fentanyl for cesarean section
Yun Wang, Wen-Xun Liu, Xiao-Hong Zhou, Min Yang, Xin Liu, Yuan Zhang, Ke-Rong Hai, Qing-Shan Ye
Yun Wang, Wen-Xun Liu, Xiao-Hong Zhou, Xin Liu, Yuan Zhang, Ke-Rong Hai, Qing-Shan Ye, The First Hospital of Northwest Minzu University (Department of Anesthesiology, People's Hospital of Ningxia Hui Autonomous Region), Yinchuan 750002, Ningxia Hui Autonomous Region, China
Min Yang, Department of Anesthesiology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, Hubei Province, China
Author contributions: Wang Y and Liu WX contributed equally to this work, and are considered co-first authors; Wang Y, Liu WX and Zhou XH analyzed and interpreted data and wrote the article; Yang M and Liu X drafted the work and collected the data; Ye QS designed the study and revised the article for important intellectual content.
Supported byFundamental Research Funds for the Central Universities of Northwest Minzu University, No. 31920160102; and 2017 Innovation and Entrepreneurship Project for Overseas Students in Ningxia (Team).
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Northwest Minzu University (No. 063).
Informed consent statement: Patients signed an informed consent.
Conflict-of-interest statement: The authors have no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qing-Shan Ye, MD, Professor, Department of Anesthesiology, People's Hospital of Ningxia Hui Autonomous Region, No. 301 Zhengyuan North Street, Jinfeng District, Yinchuan 750002, Ningxia Hui Autonomous Region, China. yeqingshan@hotmail.com
Received: January 21, 2021 Peer-review started: January 21, 2021 First decision: February 28, 2021 Revised: March 8, 2021 Accepted: May 8, 2021 Article in press: May 8, 2021 Published online: August 16, 2021 Processing time: 196 Days and 14.1 Hours
Abstract
BACKGROUND
The choice of anesthesia for cesarean section is very important.
AIM
To compare the effects of applying bupivacaine combined with different doses of fentanyl on newborns after cesarean section.
METHODS
We randomly divided one hundred and twenty patients undergoing cesarean section into the following 4 groups: group B (bupivacaine group), group BF10 (bupivacaine combined with 10 µg fentanyl), group BF30 (bupivacaine combined with 30 µg fentanyl) and group BF50 (bupivacaine combined with 50 µg fentanyl). The heart rate, mean arterial pressure, block plane fixation time and sensory block time were recorded. Umbilical artery blood was then collected immediately after fetal delivery for blood gas analysis and qualitative detection of fentanyl. Additionally, data on the neonatal 1-min and 5-min Apgar scores, results of umbilical artery blood gas analysis and qualitative detection of fentanyl in umbilical artery blood were recorded.
RESULTS
Although the mean arterial pressure decreased in all four groups at 3 min after anesthesia, the percentage of the decrease was less than 20% of the baseline. In addition, there were no significant differences in the 1-min or 5-min Apgar scores or the umbilical artery blood gas analysis among the four groups (P > 0.05). Moreover, the concentration of fentanyl in umbilical artery blood was qualitatively detected using an ELISA kit, and the results in the four groups were negative.
CONCLUSION
Bupivacaine combined with fentanyl spinal anesthesia is effective in cesarean section.
