Primary extra-pancreatic pancreatic-type acinar cell carcinoma in the right perinephric space: A case report and review of literature

Table 1 Clinical features in reported cases of acinar cell carcinoma arising from extra-pancreatic tissues

Ref.	Age/sex	Tumor location	Tumor size in cm	Metastasis, yes/no	Preoperative diagnosis	Treatment	Outcome
Bookman[10], 1932	28/F	Duodenum	NM	No	Begin: Such as polyp	Partial resection	NM
Makhlouf et al[14], 1999	71/M	Jejunum	3.5	No	NM	Partial resection	1 yr alive, liver metastasis at 1 yr
Sun and Wasserman[5], 2004	86/M	Stomach	5	No	PDA	Partial gastrectomy	NM
Mizuno et al[6], 2007	73/M	Pylorus	7	LN	GIST/ML	PD	11 mo alive, liver metastasis at 7 mo
Kawakami et al[11], 2007	65/F	AoV	1.2	No	Carcinoma of AoV	PD	19 mo alive, NR
Hervieu et al[12], 2008	35/F	Liver	4	No	HCC	Hepatectomy	6 yr alive, NR
Chiaravalli et al[13], 2009	65/F	Colon	4	LN	NM	Colonic segment resection	24 mo died with diffuse bone metastasis at 18 mo
Ambrosini et al[7], 2009	52/M	Stomach	4	No	PDA and chronic gastritis	Subtotal gastrectomy	NM
Agaimy et al[22], 2011	Case 1: 68/F	Liver	7	No	HCC	Hepatectomy	38 mo alive, NR
Agaimy et al[22], 2011	Case 2: 49/F	Liver	NM	NM	NM	Hepatectomy	28 mo alive, NR
Agaimy et al[22], 2011	Case 3: 71/M	Liver	NM	No	HCC	Hepatectomy	3 mo died
Agaimy et al[22], 2011	Case 4: 72/M	Liver	NM	NM	CCC	Hepatectomy	20 mo alive, recurrence at 18 mo
Terris et al[16], 2011	Case 1: 52/M	Peripancreatic lymph nodes	3	LN	NM	Left pancreatectomy	10 mo alive with liver metastasis
Terris et al[16], 2011	Case 2: 59/F	Lymph nodes along the biliary tract and liver hilum	NM	LN	NM	Hepatectomy	6 mo alive
Terris et al[16], 2011	Case3: 73/M	Colonic tumor and retroperitoneal lymph nodes	4	Liver	NM	Right hemicolectomy	6 mo alive with recurrence
Coyne et al[8], 2012	77/F	Stomach	4.5	No	PDA	Partial gastrectomy	NM
Hamidian Jahromi et al[3], 2013	58/M	Duodenum	2.7	No	NM	Duodenal resection	18 mo alive, NR
Yonenaga et al[4], 2016	Case 1: 67/M	Gastric body	8.5	LN	NM	Distal gastrectomy	21 mo alive, NR
Yonenaga et al[4], 2016	Case 2: 63/M	Antrum of the stomach	6.5	Liver	PDA	Chemotherapy	5 mo died of sepsis
Kim et al[9], 2017	54/M	Gastric cardia	2.7	No	GIST/ML	Laparoscopic wedge resection	33 mo alive, NR
Takagi et al[15], 2017	78/F	Jejunum	8.5	No	PDA	Partial resection and Chemotherapy	10 mo alive, NR
Our case, 2019	48/M	Right perinephric space	8	No	Paraganglioma/ renal oncocytoma	Tumor resection	15 mo alive, NR

AoV: Ampulla of Vater; CCC: Cholangiocarcinoma; F: Female; GIST: Gastrointestinal stromal tumor; HCC: Hepatocellular carcinoma; LN: Lymph node; M: Male; ML: Malignant lymphoma; NM: Not mentioned; NR: No recurrence; PD: Pancreaticoduodenectomy; PDA: Poorly differentiated carcinoma.

Table 2 Computed tomography features in reported cases of acinar cell carcinoma arising from extra-pancreatic tissues

Ref.	Tumor shape	Tumor contour, well-/ill-defined	Tumor CT image, present/absent	Ulceration, yes/no	Necrosis, yes/no	Enhancement patterns	Capsule, present/absent	Adjacent organ	Metastasis
Bookman[10], 1932	NM	Well-defined	No	NM	NM	No	NM	NM	No
Makhlouf et al[14], 1999	NM	NM	Absent	Yes	NM	NM	NM	NM	No
Sun and Wasserman[5], 2004	NM	NM	Absent	Yes	NM	NM	NM	NM	No
Mizuno et al[6], 2007	NM	NM	Present	NM	NM	Marked/heterogenous	NM	NM	LN
Kawakami et al[11], 2007	Nodular	NM	Present	NM	NM	Marked/heterogenous	NM	NM	No
Hervieu et al[12], 2008	NM	Well-defined	Absent	NM	NM	Marked	NM	NM	No
Chiaravalli et al[13], 2009	NM	NM	NM	NM	NM	NM	NM	NM	LN
Ambrosini et al[7], 2009	NM	NM	Absent	NM	NM	NM	NM	NM	No
Agaimy et al[22], 2011	NM	Well-defined	Absent	NM	NM	NM	NM	NM	No
Agaimy et al[22], 2011	Irregular	NM	Absent	NM	Yes	Marked/heterogenous	NM	NM	NM
Agaimy et al[22], 2011	NM	NM	Absent	NM	NM	NM	NM	NM	No
Agaimy et al[22], 2011	NM	NM	NM	NM	NM	NM	NM	NM	NM
Terris et al[16], 2011	NM	NM	Absent	NM	NM	NM	NM	No	LN
Terris et al[16], 2011	NM	NM	Absent	NM	NM	NM	NM	Bile duct	LN
Terris et al[16], 2011	NM	NM	NM	NM	NM	NM	NM	No	Liver
Coyne et al[8], 2012	Lobulated	Well-defined	NM	NM	NM	NM	NM	NM	No
Hamidian Jahromi et al[3], 2013	Pedunculated	NM	NM	NM	NM	NM	NM	No	No
Yonenaga et al[4], 2016	Lobulated	Well-defined	NM	NM	No	NM	NM	NM	LN
Yonenaga et al[4], 2016	Borrmann type-2 lesion	NM	NM	NM	NM	NM	NM	NM	Liver
Kim et al[9], 2017	Polypoid	Well-defined	Present	NM	NM	Marked/homogenous	NM	No	No
Takagi et al[15], 2017	NM	NM	Present	NM	NM	Marked/heterogenous	NM	First jejunal vein	No
Our case, 2019	Oval	Well-defined	Present	No	No	Marked/heterogenous	Present	No	No

CT: Computed tomography; LN: Lymph node; NM: Not mentioned.