Wei YY, Li Y, Shi YJ, Li XT, Sun YS. Primary extra-pancreatic pancreatic-type acinar cell carcinoma in the right perinephric space: A case report and review of literature. World J Clin Cases 2021; 9(20): 5637-5646 [PMID: 34307619 DOI: 10.12998/wjcc.v9.i20.5637]
Corresponding Author of This Article
Ying-Shi Sun, MD, Chief Doctor, Professor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiology, Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. sys27@163.com
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 16, 2021; 9(20): 5637-5646 Published online Jul 16, 2021. doi: 10.12998/wjcc.v9.i20.5637
Primary extra-pancreatic pancreatic-type acinar cell carcinoma in the right perinephric space: A case report and review of literature
Yi-Yuan Wei, Ying Li, Yan-Jie Shi, Xiao-Ting Li, Ying-Shi Sun
Yi-Yuan Wei, Ying Li, Yan-Jie Shi, Xiao-Ting Li, Ying-Shi Sun, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiology, Peking University Cancer Hospital & Institute, Beijing 100142, China
Author contributions: Wei YY contributed to the writing of the manuscript and designed the figures and table; Li Y and Shi YJ interpreted the radiological images and contributed to drafting the manuscript; Li XT was involved in supervising the study; Sun YS reviewed and approved the final version of this work.
Supported byBeijing Natural Science Foundation, No. Z200015; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support, No. ZYLX201803; ‘Beijing Hospitals Authority’ Ascent Plan, No. DFL20191103; and 2019SKY Imaging Research Fund of the Chinese International Medical Foundation, No. Z-2014-07-1912.
Informed consent statement: Any and all details that might disclose the identity of the patient described in this report are anonymized. Informed written consent was obtained from the patient for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying-Shi Sun, MD, Chief Doctor, Professor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiology, Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. sys27@163.com
Received: February 23, 2021 Peer-review started: February 23, 2021 First decision: March 28, 2021 Revised: March 30, 2021 Accepted: May 20, 2021 Article in press: May 20, 2021 Published online: July 16, 2021 Processing time: 134 Days and 6.3 Hours
Abstract
BACKGROUND
Primary extra-pancreatic pancreatic-type acinar cell carcinoma (ACC) is a rare malignancy, and has only been reported in the gastrointestinal tract, liver, and lymph nodes until now. Extra-pancreatic pancreatic-type ACC in the perinephric space has not been reported. Herein, we report the first case of ACC in the perinephric space and describe its clinical and imaging features, which should be considered when differentiating perinephric space neoplasms.
CASE SUMMARY
A 48-year-old man with a 5-year history of hypertension was incidentally found to have an asymptomatic right retroperitoneal mass during a routine health check-up. Laboratory tests were normal. Abdominal computed tomography and magnetic resonance imaging showed an oval hypervascular mass with a central scar and enhanced capsule in the right perinephric space. After surgical resection of the neoplasm, the diagnosis was primary extra-pancreatic pancreatic-type ACC. The patient was alive without recurrence or metastasis during a 15-mo follow-up.
CONCLUSION
This is the first report of an extra-pancreatic ACC in right perinephric space, which should be considered as a possible diagnosis in perinephric tumors.
Core Tip: Primary extra-pancreatic pancreatic-type acinar cell carcinoma (ACC) is a rare malignant tumor, with very few reported cases. Extra-pancreatic pancreatic-type ACC arising in the perinephric space has not been reported. The imaging characteristics of our case included an oval shape, relatively homogenous density or signal, a hypervascular pattern and rapid washout with enhancement, and an enhanced capsule. This report of diagnosis and treatment of this rare tumor. will be helpful for clinicians, radiologists and pathologists to differentiate this unusual tumor from other plausible retroperitoneal neoplasms. The recommended treatment for this tumor is complete surgical resection.
