Diagnostic value of two dimensional shear wave elastography combined with texture analysis in early liver fibrosis

Table 1 Distribution of patients with liver fibrosis

Pathological stage	Gender		Mean age (yr)
	Male	Female
F0	7	8	36.8 ± 11.1
F1	6	3	39.8 ± 14.9
F2	3	6	52.4 ± 8.6
F3	2	3	49.4 ± 8.1
F4	2	4	59.3 ± 9.3

Table 2 Comparison of two dimensional shear wave elastography and textural features in different groups (Median, Range)

Comparison		2D-SWE	P-value	Contrast	P-value	Correlation	P-value	ASM	P-value	Homogeneity	P value
F0 vs F1-4 ( ≥ F1)	F0	5.97 (4.07-11.03)	0.001	1.51 (0.44-6.69)	< 0.001	0.97 (0.79-0.99)	0.72	0.056 (0.015-0.87)	0.087	0.76 (0.64-0.97)	0.002
	F1-4	10.63 (6.40-44.87)		8.39 (1.39-200.76)		0.96 (0.67-0.99		0.043 (0.003-0.33)		0.54 (0.33-0.87)
F0-1 vs F2-4 ( ≥ F2)	F0-1	7.78 (4.07-17.43)	< 0.001	2.66 (0.44-19.64)	< 0.001	0.97 (0.79-0.99)	0.041	0.05 (0.015-0.87)	0.11	0.69 (0.59-0.97)	0.007
	F2-4	11.94 (6.4-44.87)		11.78 (1.39-200.76)		0.94 (0.66-0.98)		0.034 (0.003-0.33)		0.61 (0.33-0.87)
F0-2 vs F3-4 ( ≥ F3)	F0-2	9.03 (4.07-17.43)	< 0.001	3.39 (0.44-27.43)	0.002	0.96 (0.79-0.99)	0.23	0.049 (0.012-0.87)	0.11	0.68 (0.50-0.97)	0.044
	F3-4	14.97 (9.00-44.87)		14.86 (1.39-200.76)		0.94 (0.67-0.98)		0.030 (0.003-0.33)		0.59 (0.33-0.87)
F0-3 vs F4 (F4)	F0-3	9.42 (4.07-22.23)	0.004	3.69 (0.44-67.49)	< 0.001	0.96 (0.74-0.99)	0.29	0.05 (0.012-0.87)	0.018	0.68 (0.50-0.97)	0.018
	F4	17.30 (9.00-44.87)		90.43 (9.34-200.76)		0.93 (0.67-0.98)		0.019 (0.003-0.094)		0.50 (0.33-0.69)

2D-SWE: Two dimensional shear wave elastography; ASM: Angular second moment.

Table 3 Receiver operating characteristic curve analysis of various indicators in diagnosing pathological stages of liver fibrosis

		2D SWE	Contrast	Correlation	ASM	Homogeneity	PRE
F0 vs F1-4 (≥ F1)	AUC (95%CI)	0.823 (0.678-0.921)	0.906 (0.779-0.973)	0.533 (0.377-0.685)	0.659 (0.500-0.795)	0.789 (0.639-0.897)	0.952 (0.841-0.994)1
	P	< 0.0001	< 0.0001	0.735	0.09	< 0.0001	< 0.0001
	YI	0.533	0.697	0.195	0.363	0.448	0.761
	Cutoff	> 5.967	> 2.726	≤ 0.899	≤ 0.0940	≤ 0.632	> 0.591
	TPR (%)	100.0	89.7	13.8	89.7	44.8	82.8
	TNR (%)	53.3	80.0	66.7	46.7	100.0	93.3
F0-1 vs F2-4 (≥ F2)	AUC (95%CI)	0.808 (0.662-0.911)	0.835 (0.693-0.930)	0.680 (0.523-0.813)	0.641 (0.482-0.780)	0.736 (0.582-0.858)	0.896 (0.766-0.967)
	P	< 0.0001	< 0.0001	0.0267	0.0936	0.0023	< 0.0001
	YI	0.483	0.567	0.358	0.258	0.508	0.767
	Cutoff	> 8.667	> 7.391	≤ 0.973	≤ 0.0350	≤ 0.617	> 0.440
	TPR (%)	90.0	65.0	90.0	55.0	55.0	85.0
	TNR (%)	58.3	91.7	45.8	70.8	95.8	91.7
F0-2 vs F3-4 (≥ F3)	AUC (95%CI)	0.920 (0.798-0.980)	0.807 (0.660-0.910)	0.624 (0.465-0.765)	0.663 (0.504-0.798)	0.705 (0.549-0.883)	0.978 (0.881-0.999)
	P	< 0.0001	0.0002	0.21	0.107	0.0392	< 0.0001
	YI	0.818	0.546	0.273	0.363	0.485	0.939
	Cutoff	> 11.033	> 8.385	≤ 0.938	≤ 0.0330	≤ 0.587	> 0.124
	TPR (%)	90.9	72.7	54.6	63.6	54.6	100.0
	TNR (%)	90.9	81.8	72.7	72.7	93.9	93.9
F0-3 vs F4 (F4)	AUC (95%CI)	0.855 (0.716-0.943)	0.925 (0.805-0.983)	0.638 (0.480- 0.777)	0.796 (0.648-0.902)	0.798 (0.650-0.904)	0.947 (0.835-0.992)
	P	< 0.0001	< 0.0001	0.272	0.0058	0.0058	< 0.0001
	YI	0.702	0.790	0.377	0.597	0.561	0.807
	Cutoff	> 13.000	> 8.385	≤ 0.938	≤ 0.030	≤ 0.587	> 0.383
	TPR (%)	83.3	100.0	66.7	83.3	66.7	83.3
	TNR (%)	86.8	79.0	71.1	76.3	89.5	97.4

¹There is statistically significance when compared with two dimensional shear wave elastography group (P < 0.05).

PRE: Predictive value of combined diagnosis; AUC: The area under the ROC curve; YI: Youden index; Cutoff: The diagnostic cut-off point; TPR: The true positive rate; TNR: The true negative rate.