Serum inflammatory markers in children with Mycoplasma pneumoniae pneumonia and their predictive value for mycoplasma severity

Table 1 Baseline characteristics of the studied population, n (%)

	Severe MPP (n = 80)	Mild MPP (n = 80)	P value
Sex (male, %)	38 (47.5)	43 (53.8)	0.362
Age, yr	6.82 ± 2.55	7.63 ± 2.67	0.287
Asthma	20 (25)	4 (5)	0.001
Allergic rhinitis	36 (45)	32 (40)	0.325
Fever time, d	6.54 ± 2.83	3.65 ± 1.81	0.001
Hospital stay, d	9.25 ± 2.53	6.54 ± 2.58	0.001
Oxygen need	80 (100)	5 (6.25)	0.001
PICU stay, d	3.62 ± 1.53	0	0.001
PIBO	18 (22.5)	0	0.001
Pleural effusion	16 (20)	0	0.001
Macrolide-resistant MPP	74 (92.5)	32 (40)	0.001
Extrapulmonary manifestations	48 (60)	2 (2.5)	0.001
Lung consolidation	58 (72.5)	4 (5)	0.001

Data are presented as mean ± standard deviation, n (%), or median (interquartile range). SMPP: Severe mycoplasma pneumoniae pneumonia; PICU: Pediatric intensive care unit; PIBO: Postinfectious bronchiolitis obliterans; MPP: Mycoplasma pneumoniae pneumonia.

Table 2 Inflammatory cytokines and laboratory findings between severe mycoplasma pneumoniae pneumonia group and mild group

	Severe MPP (n = 80)	Mild MPP (n = 80)	P value
WBC (109/L)	8.5 ± 1.2	7.6 ± 1.4	0.386
CRP (mg/L)	21.4 ± 5.8	5.4 ± 2.6	0.001
PCT (ng/mL)	0.25 ± 0.12	0.05 ± 0.01	0.001
ESR (mm/h)	32.6 ± 7.9	15.8 ± 4.6	0.001
Albumin (g/L)	39.4 ± 4.2	40.5 ± 3.8	0.412
LDH (U/L)	484.2 ± 61.4	246.9 ± 54.6	0.001
D-dimer (mg/L)	1.2 ± 0.6	0.35 ± 0.14	0.001
IL-6 (pg/mL)	25.7 ± 5.6	10.6 ± 3.8	0.001
IL-8 (pg/mL)	102.4 ± 38.8	28.6 ± 14.3	0.001
IL-10 (pg/mL)	36.6 ± 8.9	8.4 ± 2.6	0.001
TNF-α (pg/mL)	26.6 ± 6.5	12.2 ± 4.4	0.001

Data are presented as mean ± SD. SMPP: Severe mycoplasma pneumoniae pneumonia; WBC: White blood cell count; CRP: C-reactive protein; PCT: Procalcitonin; ESR: Erythrocyte sedimentation rate; LDH: Lactic dehydrogenase; IL: Interleukin.

Table 3 Logistic regression analysis predictors of severe Mycoplasma pneumoniae pneumonia

Factors	OR	95%CI	P value
CRP	3.24	1.36-6.38	0.267
PCT	1.6	1.41-3.81	0.564
ESR	2.45	1.36-4.64	0.642
LDH	2.83	1.58-5.90	0.001
IL-6	4.82	3.26-8.92	0.001
IL-8	5.23	4.42-7.85	0.415
IL-10	8.96	6.28-12.56	0.001
TNF-α	5.85	4.23-7.94	0.001
D-dimer	1.88	1.28-2.58	0.001
Lung consolidation	9.24	6.56-12.48	0.001
Extrapulmonary manifestations	7.24	5.12-10.26	0.001
Pleural effusion	4.42	3.15-6.22	0.524
Macrolide-resistant MPP	8.27	6.82-16.74	0.001
Asthma	4.27	3.56-9.56	0.001

CRP: C-reactive protein; PCT: Procalcitonin; ESR: Erythrocyte sedimentation rate; LDH: Lactic dehydrogenase; IL: Interleukin; TNF-α: Tumor necrosis factor–α; MPP: Mycoplasma pneumoniae pneumonia.