Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2024; 12(22): 4940-4946
Published online Aug 6, 2024. doi: 10.12998/wjcc.v12.i22.4940
Serum inflammatory markers in children with Mycoplasma pneumoniae pneumonia and their predictive value for mycoplasma severity
Li-Ping Wang, Zhong-Hua Hu, Jun-Sheng Jiang, Jie Jin
Li-Ping Wang, Zhong-Hua Hu, Jun-Sheng Jiang, Department of Pediatrics, The First People's Hospital of Linping District, Hangzhou 310000, Zhejiang Province, China
Jie Jin, Department of Pediatrics, Changzhou Children Hospital, Changzhou 213100, Jiangsu Province, China
Author contributions: Wang LP wrote the main manuscript text; Hu ZH prepared the related review; Jiang JS was responsible for supporting and supervising; Jin J prepared the figure and Table; All authors reviewed the manuscript.
Institutional review board statement: The study was approved by the First People's Hospital of Linping District Ethics Commit (No: linping2023044).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All authors declare that there is no conflict of interest.
Data sharing statement: Not applicable.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Jin, MD, Chief, Department of Pediatrics, Changzhou Children Hospital, Tianning District Zhonghu Strict, Changzhou 213100, Jiangsu Province, China. 3355144716@qq.com
Received: March 8, 2024
Revised: May 26, 2024
Accepted: June 14, 2024
Published online: August 6, 2024
Processing time: 115 Days and 21.1 Hours
Abstract
BACKGROUND

Mycoplasma pneumoniae pneumonia (MPP) significantly impacts pediatric health, necessitating markers for early severe disease identification.

AIM

To investigate the correlation between serum inflammatory marker and the severity of MPP in children.

METHODS

A prospective study was carried out from January 2023 to November 2023. A total of 160 children with MPP who underwent treatment were selected: 80 had severe MPP and 80 had mild MPP. Clinical and laboratory data were collected at the time of hospital admission and during hospitalization. Receiver operating characteristic curves were utilized to assess the diagnostic and prognostic for severe MPP.

RESULTS

Fever duration and length of hospitalization in pediatric patients with severe MPP exceeded those with mild MPP. The incidence of pleural effusion, lung consolidation, and bronchopneumonia on imaging was markedly elevated in the severe MPP cohort compared to the mild MPP cohort. In contrast to the mild cohort, there was a notable increase in C-reactive protein (CRP), procalcitonin (PCT), erythrocyte sedimentation rate, lactic dehydrogenase, D-dimer, and inflammatory cytokines [interleukin (IL)-6, IL-8, IL-10 and tumor necrosis factor (TNF)-α] in the severe MPP group were significantly higher.

CONCLUSION

Serum inflammatory markers (CRP, PCT, IL-6, D-dimer, IL-10 and TNF-α) were considered as predictors in children with severe MPP.

Keywords: Cytokine; Mycoplasma pneumoniae pneumonia; Children, Community-acquired pneumonia levels; Interleukin-6; D-dimer

Core Tip: This study highlights the significant correlation between elevated serum inflammatory markers and severity of Mycoplasma pneumoniae pneumonia (MPP) in children. Key markers such as C-reactive protein, procalcitonin, erythrocyte sedimentation rate, lactic dehydrogenase, D-dimer, and cytokines [interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor] serve as valuable predictors for severe MPP, aiding in early diagnosis and improved prognosis.