Neurocutaneous melanosis with an intracranial cystic-solid meningeal melanoma in an adult: A case report and review of literature

Table 1 Clinical data from the published cases of neurocutaneous melanosis in adults

Ref.	Age (yr)/sex	CMN location	Neurological symptoms	Neurological tumor location	Hydrocephalus	Surgery	Pathology	Chemotherapy/radiotherapy	Follow-up
Frisoni et al[28]	20/M	Back, neck, trunk	Weakness of right lower limb	Left pons	No	None	Unknown	None	Unknown
Vadoud-Seyedi et al[29]	50/F	Back, neck, trunk, limbs	Depression, intracranial hypertension for 4 mo	Right temporal lobe	Yes	STR	Meningeal melanoma	None	3 wk, death
Arunkumar et al[30]	24/M	Face	Epilepsy for 5 yr	Left frontal lobe, right sphenoid	Yes	STR	Meningeal melanoma	None	48 h, death
Peretti-Viton et al[31]	19/M	Back, hip	Intracranial hypertension for 4 mo	Left fronto- parietal temporal lobe, diffuse	Yes	None	Meningeal melanocytosis	None	2 mo, death
Shinno et al[10]	35/M	Sporadic	Intracranial hypertension for 2 mo	Right fronto- temporal lobe, diffuse	No	VPS	Meningeal melanomatosis	Chemotherapy	30 mo, death
de Andrade et al[32]	21/F	Lower back	Epilepsy started at the age of 7	Bilateral temporal lobe, pons	No	None	Unknown	None	> 10 yr
Tartler et al[8]	36/M	Lower back, hip	Epilepsy for 1 yr	Left temporal lobe	No	STR, VPS	Meningeal melanoma	Radiotherapy, chemotherapy	Unknown
Kang et al[15]	29/M	Sporadic	Intracranial hypertension for 3 yr, Dandy-Walker syndrome	Bilateral temporal lobe	No	STR	Meningeal melanocytoma	None	Unknown
Kiecker et al[11]	42/M	Head	Right limb weakness, hemianopia, aphasia for 3 wk	Left temporal occipital lobe	No	GTR	Meningeal melanoma	Chemotherapy	8 mo, relapse
Chute et al[33]	43/M	Head, trunk, limbs	Epilepsy for 5 yr	Left temporal lobe	No	None	Meningeal melanoma	None	5 yr, death
Zhang et al[34]	25/M	Abdomen, chest, back	Intracranial hypertension for 4 mo	Diffuse, sulcus	Yes	VPS	Meningeal melanocytosis	None	4 mo, death
Walbert et al[6]	30/F	Sporadic	Epilepsy for 5 yr, Dandy-Walker syndrome	Diffuse	Yes	VPS, GTR	Meningeal melanoma	Radiotherapy, chemotherapy	> 12 mo
Ge et al[35]	37/M	Left arm	Intracranial hypertension for 1 yr	Right frontal parietal lobe	No	STR	Meningeal melanoma	None	8 d, death
Kurokawa et al[36]	40/F	Trunk	Left leg feels abnormal and weak for 2 yr	T10 cord	No	GTR	Meningeal melanocytoma	None	> 4 yr
Oliveira et al[37]	29/F	Trunk	Epilepsy for 4 mo	Diffuse	No	STR	Meningeal melanomatosis	None	21 d, death
Matsumura et al[7]	44/M	Trunk, lower limbs	Epilepsy, memory loss	Brain and spine, diffuse	Yes	None	Meningeal melanomatosis	Chemotherapy	6 mo, death
Bhatia et al[5]	35/M	Trunk, back	Intracranial hypertension for 6 mo	Brain and spine, diffuse	Yes	VPS	Meningeal melanomatosis	Chemotherapy	Unknown
Kolin et al[25]	67/M	Trunk, back	Epilepsy for 6 mo	Meninges, diffuse	Yes	None	Meningeal melanomatosis	Radiotherapy	Unknown
Ma et al[16]	34/F	Trunk, abdomen, head, lower limbs	Intracranial hypertension for 1 wk	Left temporal lobe	No	GTR	Meningeal melanoma	None	22 mo, death
Alessandro et al[9]	20/F	Sporadic	Epilepsy for 18 mo	Right temporal lobe, diffuse	Yes	VPS	Meningeal melanocytosis	Chemotherapy	1 mo, death
Present report	41/F	Trunk, back, neck	Intracranial hypertension for 1 mo	Left temporal lobe	No	GTR	Meningeal melanoma	None	5 mo, death
Araújo et al[38]	30/F	Back, left thigh	Impaired vision, intracranial hypertension for 1 wk	Frontal lobe, cervical vertebrae	No	STR	Meningeal melanoma	Radiotherapy	7 mo, death

F: Female; M: Male; GTR: Gross total resection; STR: Subtotal resection; VPS: Ventricular-peritoneal shunt.

Table 2 KM curve

Age (yr)	Sex	Multifocla or diffuse	Hydrocephalus	Tumor resection	Chemotherapy	Radiotherapy	follow up (d)	Vital status
37	M	No	No	Yes	No	No	8	Dead
50	F	No	Yes	Yes	No	No	21	Dead
29	F	Yes	No	Yes	No	No	21	Dead
20	F	Yes	Yes	No	Yes	No	30	Dead
19	M	Yes	Yes	No	No	No	60	Dead
25	M	Yes	Yes	No	No	No	120	Dead
41	F	No	No	Yes	No	No	150	Dead
44	M	Yes	Yes	No	Yes	No	182	Dead
30	F	Yes	No	Yes	No	Yes	210	Dead
42	M	No	No	Yes	Yes	No	240	Alive
30	F	Yes	Yes	Yes	Yes	Yes	365	Alive
34	F	No	No	Yes	No	No	660	Dead
35	M	Yes	No	No	Yes	No	900	Dead
40	F	No	No	Yes	No	No	1460	Alive
21	F	Yes	No	No	No	No	1825	Alive
43	M	No	No	No	No	No	1825	Dead

Table 3 Log rank

Variables	P value
Sex	0.669
Multifocal or diffuse	0.752
Hydrocephalus	0.086
Tumor resection	0.788
Chemotherapy	0.636
Radiotherapy	0.614