Liu BC, Wang YB, Liu Z, Jiao Y, Zhang XF. Neurocutaneous melanosis with an intracranial cystic-solid meningeal melanoma in an adult: A case report and review of literature. World J Clin Cases 2022; 10(15): 5025-5035 [PMID: 35801056 DOI: 10.12998/wjcc.v10.i15.5025]
Corresponding Author of This Article
Xian-Feng Zhang, PhD, Full Professor, Department of Neurosurgery, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130021, Jilin Province, China. zhangxianf@jlu.edu.cn
Research Domain of This Article
Neurosciences
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. May 26, 2022; 10(15): 5025-5035 Published online May 26, 2022. doi: 10.12998/wjcc.v10.i15.5025
Neurocutaneous melanosis with an intracranial cystic-solid meningeal melanoma in an adult: A case report and review of literature
Bo-Chuan Liu, Yu-Bo Wang, Zhuang Liu, Yan Jiao, Xian-Feng Zhang
Bo-Chuan Liu, Department of Neurosurgery, The Second Affiliated Hospital of Xi'an Medical University, Xi'an 710038, Shaanxi Province, China
Yu-Bo Wang, Xian-Feng Zhang, Department of Neurosurgery, First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Zhuang Liu, Department of Neurosurgery, Dongfeng County Hospital, Liaoyuan 136300, Jilin Province, China
Yan Jiao, Department of Hepatobiliary and Pancreatic Surgery, First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Liu BC and Wang YB contributed equally to this work; Liu BC and Zhang XF diagnosed the patient; Liu BC analyzed the literature data; and All authors wrote and revised the manuscript and issued the final approval for the version to be submitted.
Informed consent statement: Informed written consent has been obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that there are no any conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist(2016), and the manuscript was prepared and revised according to the CARE Checklist(2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xian-Feng Zhang, PhD, Full Professor, Department of Neurosurgery, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130021, Jilin Province, China. zhangxianf@jlu.edu.cn
Received: December 7, 2021 Peer-review started: December 7, 2021 First decision: January 25, 2022 Revised: February 12, 2022 Accepted: March 26, 2022 Article in press: March 26, 2022 Published online: May 26, 2022 Processing time: 168 Days and 0.7 Hours
Abstract
BACKGROUND
Neurocutaneous melanosis (NCM) is a rare congenital, nonhereditary neurocutaneous syndrome that mainly occurs in children; adult NCM is very rare. Due to its rarity, the clinical features and treatment strategies for NCM remain unclear. The purpose of this study was to explore the clinical features, diagnosis, treatment and prognosis of NCM in adults. Most intracranial meningeal melanomas are solid masses, and cystic-solid malignant melanomas are very rare. Due to the lack of data, the cause of cystic changes and the effect on prognosis are unknown.
CASE SUMMARY
A 41-year-old woman was admitted to the hospital with intermittent headache for 1 mo. Magnetic resonance imaging (MRI) showed a 4.7 cm × 3.6 cm cystic-solid mass in the left temporal lobe with peritumoral edema. The entire mass was removed, and postoperative pathology indicated malignant melanoma.
CONCLUSION
MRI is the first-choice imaging approach for diagnosing central nervous system diseases in NCM patients, although cerebrospinal fluid may also be used. At present, there is no optimal treatment plan; gross total resection combined with BRAF inhibitors and MEK inhibitors might be the most beneficial treatment.
Core Tip: Neurocutaneous melanosis (NCM) is a rare congenital, nonhereditary neurocutaneous syndrome that mainly occurs in children, while adult NCM is very rare. Due to its rarity, clinical features and treatment strategies for NCM remain unclear. Herein, we report a case and review such reports and explore the clinical features, diagnosis, treatment and prognosis of NCM in adults.
