Endoscopic ultrasonography in the evaluation of condition and prognosis of ulcerative colitis

Table 1 Scoring criteria of ulcerative colitis endoscopic index of severity

Items	0 score	1 score	2 score	3 score
Erosion and ulcer	Normal	Erosion, rough	The surface is covered with white moss, erosive and rough	Deep concave ulcer
Bleeding	No	Old blood stains, and disappear after washing with water	Blood stain, oozes again after washing with water	Active bleeding
Vascular texture	Normal	Vague	Disappear	-

Table 2 Scoring criteria of endoscopic ultrasonography-ulcerative colitis

Items	0 score	1 score	2 score	3 score
Intestinal wall thickness	Normal (≤ 3 mm)	Mild (3.1-4 mm)	Moderate (4.1-6 mm)	Severe (≥ 6.1 mm)
Depth of inflammation	1 layer involved	1-3 layer involved	Muscle layer involved	Transmural
Hyperemia	No	Mild	Moderate	Severe

Table 3 Scoring criteria of modified Truelove and Witts scores

Severity	ESR (mm/1 h)	Hemoglobin	Temperature (℃)	P (times/min)	Hematochezia	Defecation times (times/d)
Mild	< 20	Normal	Normal	Normal	Mild or no	< 4
Severe	> 30	< 75% normal value	> 37.8℃	> 90	Severe	≥ 6
Moderate	Between mild and severe

ESR: Erythrocyte sedimentation rate

Table 4 Evaluation criteria of Mayo

Item	0 score	1 score	2 score	3 score
Defecation times	Normal	More times than normal 1-2 times/d	More times than normal 3-4 times/d	More times than normal at least 5 times/d
Hematochezia	No	Blood in the stool less than half the time	Most of the time there is blood in the stool	There is always blood in the stool
-	Normal	Mild	Moderate	Severe

Table 5 Comparison of ulcerative colitis endoscopic index of severity and endoscopic ultrasonography-ulcerative colitis scores of patients with different Mayo scores (mean ± SD, scores)

Groups	Cases	UCEIS	EUS-UC
Mild	23	1.56 ± 0.82	1.64 ± 0.91
Moderate	32	4.98 ± 1.04	5.01 ± 0.99
Severe	24	7.31 ± 1.10	7.59 ± 1.02
t/P value (mild vs moderate)		13.102/0.000	12.874/0.000
t/P value (moderate vs severe)		8.095/0.000	9.527/0.000

UCEIS: Ulcerative colitis endoscopic index of severity; EUS-UC: Endoscopic ultrasonography-ulcerative colitis scores.

Table 6 Comparison of ulcerative colitis endoscopic index of severity and endoscopic ultrasonography-ulcerative colitis scores of patients with different modified Truelove and Witts scores (mean ± SD, scores)

Groups	Cases	UCEIS	EUS-UC
Mild	21	1.71 ± 0.78	1.69 ± 0.88
Moderate	36	4.79 ± 1.11	4.96 ± 1.23
Severe	22	7.68 ± 1.22	7.81 ± 0.90
t/P value (mild vs moderate)		11.187/0.000	10.676/0.000
t/P value (moderate vs severe)		9.266/0.000	9.422/0.000

UCEIS: Ulcerative colitis endoscopic index of severity; EUS-UC: Endoscopic ultrasonography-ulcerative colitis scores.

Table 7 The correlation analysis between ulcerative colitis endoscopic index of severity, endoscopic ultrasonography-ulcerative colitis scores and disease severity

Items		UCEIS	EUS-UC
Modified Truelove and Witts score	r value	0.537	0.559
	P value	< 0.001	< 0.001
Mayo score	r value	0.498	0.603
	P value	< 0.001	< 0.001

UCEIS: Ulcerative colitis endoscopic index of severity; EUS-UC: Endoscopic ultrasonography-ulcerative colitis scores.

Table 8 Comparison of ulcerative colitis endoscopic index of severity and endoscopic ultrasonography-ulcerative colitis scores before and after treatment (mean ± SD, scores)

Time	Cases	UCEIS	EUS-UC
Before treatment	79	5.93 ± 1.79	6.04 ± 2.01
2 mo after treatment	79	3.88 ± 0.95	4.01 ± 1.14
6 mo after treatment	79	1.59 ± 0.63	1.64 ± 0.59
t/P value (2 mo after treatment vs before treatment)		8.991/0.000	7.808/0.000
t/P value (6 mo after treatment vs before treatment)		20.328/0.000	18.669/0.000

UCEIS: Ulcerative colitis endoscopic index of severity; EUS-UC: Endoscopic ultrasonography-ulcerative colitis scores.