Published online May 26, 2022. doi: 10.12998/wjcc.v10.i15.4818
Peer-review started: January 6, 2022
First decision: February 7, 2022
Revised: February 17, 2022
Accepted: March 26, 2022
Article in press: March 26, 2022
Published online: May 26, 2022
Processing time: 138 Days and 4.3 Hours
Ulcerative colitis (UC) is usually diagnosed through histopathology, enteroscopy, clinical symptoms, and physical findings; however, it is difficult to accurately evaluate disease severity.
In this study, the UC endoscopic index of severity (UCEIS) and endoscopic ultrasonography (EUS)-UC scores of patients were assessed in relation to disease severity, and the correlations between UCEIS and EUS-UC scores and disease severity was also analyzed.
This study investigated the value of EUS in the evaluation of the severity and prognosis of ulcerative colitis.
Patients who underwent endoscopic ultrasound to investigate UC at our hospital were eligible for enrollment. A Fujinon SP701 micro ultrasonic probe, with frequency of 20 MHz and rotary scanning mode, and a Fujifilm SU-9000 ultrasonic probe with frequencies of 7.5, 10, and 12 MHz were used. Disease severity was evaluated using the Mayo scale and the modified Truelove and Witts scores. Treatments included oral mesalazine with or without corticosteroids, and intravenous infusion of infliximab. Colonoscopy was repeated 2 and 6 mo after the initiation of treatment.
The UCEIS and EUS-UC scores were higher in moderate cases than in mild cases. The UCEIS and EUS-UC scores were higher still in severe cases than in moderate cases, and the differences were statistically significant. The UCEIS and EUS-UC scores in moderate cases were higher than in mild cases. The UCEIS and EUS-UC scores in severe cases were higher than in moderate cases, and the differences were statistically significant. The UCEIS and EUS-UC scores were significantly and positively correlated with disease severity. The UCEIS and EUS-UC scores after 2 mo of treatment and after 6 mo of treatment were lower than the UCEIS and EUS-UC scores before treatment.
EUS can effectively clarify the disease status of patients with ulcerative colitis, stratify the disease severity, and accurately evaluate the treatment response, to provide an objective basis for the clinical formulation or further adjustment of a patient’s treatment plan.
We will study the application value of this scheme in individualized therapy.