Autophagy-related long non-coding RNA prognostic model predicts prognosis and survival of melanoma patients

Table 1 Clinical correlation analysis in melanoma patients

Variable	Group	n	Mean	SD	t value	P value
Age	≤ 65	228	1.25	0.788	-2.14416	0.033
	> 65	121	1.488	1.081
Gender	Female	133	1.323	1.016	-0.1461	0.884
	Male	216	1.338	0.834
Stage	I-II	194	1.283	0.801	-1.10172	0.272
	III-IV	155	1.394	1.022
T	0-2	135	1.155	0.747	-3.10656	0.002
	3-4	214	1.444	0.978
M	0	338	1.336	0.912	0.502769	0.625
	1	11	1.223	0.727
N	0	202	1.281	0.8	-1.19357	0.234
	1-3	147	1.403	1.033

Table 2 Fifty-two lncRNAs associated with survival in melanoma patients identified by univariate Cox proportional risk analysis

LncRNA	HR	Lower limit (95%CI)	Upper limit (95%CI)	P value	Risk
C5orf56	0.478	0.348	0.656	0.000	Low
AC011899.2	0.588	0.437	0.792	0.000	Low
AC098613.1	0.595	0.456	0.776	0.000	Low
AC068282.1	0.617	0.448	0.851	0.003	Low
LINC01943	0.627	0.500	0.786	0.000	Low
AP002807.1	0.630	0.464	0.856	0.003	Low
AL590764.1	0.634	0.496	0.811	0.000	Low
LINC00324	0.635	0.517	0.779	0.000	Low
ZEB1-AS1	0.659	0.531	0.817	0.000	Low
VIM-AS1	0.659	0.533	0.816	0.000	Low
LINC02328	0.662	0.504	0.870	0.003	Low
MMP25-AS1	0.674	0.544	0.835	0.000	Low
AC015911.3	0.674	0.553	0.821	0.000	Low
AL662844.4	0.688	0.526	0.901	0.007	Low
AL137003.2	0.689	0.544	0.871	0.002	Low
MIAT	0.701	0.575	0.854	0.000	Low
AL133371.2	0.707	0.587	0.852	0.000	Low
AC022706.1	0.713	0.569	0.895	0.003	Low
U62317.1	0.714	0.580	0.879	0.002	Low
AC090948.3	0.727	0.574	0.921	0.008	Low
AC011374.2	0.735	0.608	0.888	0.001	Low
AC242842.1	0.741	0.639	0.859	0.000	Low
AC004918.1	0.756	0.629	0.908	0.003	Low
TRG-AS1	0.763	0.643	0.905	0.002	Low
DBH-AS1	0.777	0.664	0.910	0.002	Low
AC018755.4	0.779	0.670	0.906	0.001	Low
AC060766.7	0.782	0.658	0.929	0.005	Low
AC090559.1	0.789	0.680	0.916	0.002	Low
USP30-AS1	0.803	0.732	0.880	0.000	Low
PAXIP1-AS2	0.806	0.706	0.919	0.001	Low
AL365361.1	0.814	0.719	0.922	0.001	Low
AC012236.1	0.835	0.741	0.941	0.003	Low
HLA-DQB1-AS1	0.835	0.765	0.912	0.000	Low
TRBV11-2	0.838	0.738	0.950	0.006	Low
AC093726.1	0.844	0.772	0.923	0.000	Low
AL157871.2	0.847	0.759	0.945	0.003	Low
MIR155HG	0.848	0.775	0.928	0.000	Low
AC243960.1	0.854	0.774	0.942	0.002	Low
AC083799.1	0.871	0.817	0.927	0.000	Low
LINC02446	0.873	0.809	0.941	0.000	Low
ITGB2-AS1	0.875	0.793	0.966	0.008	Low
AC004687.1	0.881	0.813	0.955	0.002	Low
PCED1B-AS1	0.914	0.865	0.964	0.001	Low
WAC-AS1	0.916	0.876	0.959	0.000	Low
LINC01871	0.918	0.880	0.957	0.000	Low
PSMB8-AS1	0.944	0.920	0.969	0.000	Low
THCAT158	0.952	0.923	0.981	0.001	Low
HCP5	0.975	0.964	0.986	0.000	Low
KU-MEL-3	1.006	1.002	1.010	0.003	High
LINC00520	1.011	1.005	1.017	0.001	High
AC100791.3	1.186	1.067	1.318	0.001	High
AC018553.1	1.255	1.129	1.396	0.000	High

HR: Hazard ratio.

Table 3 Prognostic melanoma risk model based on multivariate Cox proportional hazards analysis

LncRNA	Coefficient	HR	Risk
LINC01943	-0.265	0.768	Low
AC090948.3	-0.282	0.754	Low
USP30-AS1	-0.206	0.814	Low
AC068282.1	-0.253	0.776	Low
AC004687.1	-0.152	0.859	Low
AL133371.2	-0.253	0.777	Low
AC242842.1	-0.209	0.812	Low
PCED1B-AS1	0.229	1.258	High
HLA-DQB1-AS1	-0.096	0.909	Low
AC011374.2	-0.218	0.804	Low
LINC00324	-0.231	0.794	Low
ITGB2-AS1	0.188	1.206	High
AC018553.1	0.121	1.128	High
LINC00520	0.01	1.01	High
DBH-AS1	0.259	1.296	High

HR: Hazard ratio.