Gastric mixed adenoma-neuroendocrine tumor: A case report

Figure 1 Gastroendoscopy findings. Endoscopic findings showed granular superficial elevated (0-IIa) lesion with a maximum diameter of 10 mm on the anterior wall of the gastric body.

Figure 2 Pathologic examination. Microscopic examination (hematoxylin and eosin-stain) of biopsy specimen showed many ducts for adenomas, but some of them have structural atypical ducts, suggesting well-differentiated adenocarcinoma.

Figure 3 Pathologic examination. Microscopic examination (hematoxylin and eosin -stain) of resected gastric membrane showed mixture of superficial mucosal adenoma and deep mucosal neuroendocrine tumor.

Figure 4 Immunohistochemical staining for synaptophysin, chromogranin, Ki-67, and p-53. A: Immunohistochemical staining with synaptophysin showed diffuse staining in the cytoplasm of neuroendocrine tumor (NET); B: Immunohistochemical staining with chromogranin slightly stained the NET cytoplasm; C: Immunohistochemical staining with Ki-67 showed a MIB-1 index of 1% or less in the NET region; D: Immunohistochemical staining with p-53 showed almost no staining.