Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2020; 8(22): 5744-5750
Published online Nov 26, 2020. doi: 10.12998/wjcc.v8.i22.5744
Gastric mixed adenoma-neuroendocrine tumor: A case report
Shuzo Kohno, Hiroaki Aoki, Masayuki Kato, Masaich Ogawa, Kazuhiko Yoshida
Shuzo Kohno, Hiroaki Aoki, Masaich Ogawa, Kazuhiko Yoshida, Department of Surgery, The Jikei University Katsushika Medical Center, Tokyo 125-8506, Katsushika-ku, Japan
Masayuki Kato, Department of Endoscopy, The Jikei University Katsushika Medical Center, Tokyo 125-8506, Katsushika-ku, Japan
Author contributions: Kohno S wrote the paper; Kato M contributed to endoscopic diagnosis and explanation; Aoki H, Ogawa M and Yoshida K revised the manuscript for final submission.
Informed consent statement: We have obtained the patient's consent for this case report.
Conflict-of-interest statement: The authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shuzo Kohno, MD, PhD, Associate Professor, Department of Surgery, The Jikei University Katsushika Medical Center, 6-41-2 Aoto, Tokyo 125-8506, Katsushika-ku, Japan. s-kohno@jikei.ac.jp
Received: August 6, 2020
Peer-review started: August 6, 2020
First decision: August 22, 2020
Revised: September 12, 2020
Accepted: September 23, 2020
Article in press: September 23, 2020
Published online: November 26, 2020
Processing time: 111 Days and 7.2 Hours
Abstract
BACKGROUND

Gastric mixed adenoma-neuroendocrine tumors (NETs) are quite rare. In the 2019 world health organization classification of tumors of the digestive system, these were designated as a combination of grade 1 or grade 2 NETs and adenomas or tubular adenomas. There are no treatment guidelines for these tumors, and pathological and clinical studies are ongoing. Herein, we review previous case reports and present a case of gastric mixed adenoma-NET.

CASE SUMMARY

A 66-year-old man underwent gastrointestinal endoscopy for the evaluation of upper abdominal pain. Histopathological examination of the biopsy specimen indicated the possibility of gastric cancer. A histopathological examination by endoscopic submucosal dissection showed a mixed adenoma-NET that was completely excised by endoscopic submucosal dissection. No recurrence was observed on gastrointestinal endoscopy at the 6-mo follow-up.

CONCLUSION

Clinicians' awareness of this rare tumor is important for its timely diagnosis and treatment.

Keywords: Adenoma; Neuroendocrine tumor; Diagnosis; Pathology; Stomach treatment; Case report

Core Tip: Neuroendocrine tumors are rare tumors, and analysis and classification of tumors have progressed due to recent advances in immunostaining and gene analysis. The mixture of gastric adenoma or adenocarcinoma with neuroendocrine tumor is quite rare, and it is interesting to investigate the mechanism of tumor development and differentiation. We experienced a case of mixed adenoma- neuroendocrine tumors and considered problems in diagnosis and treatment, so we will report it together with other reported cases.