Role of triggering receptor expressed on myeloid cells 1/2 in secondary injury after cerebral hemorrhage

Figure 1 Triggering receptor expressed on myeloid cells signaling pathway. TLR: Toll-like receptor; TREM: Triggering receptor expressed on myeloid cells; sTREM-1: Soluble triggering receptor expressed on myeloid cells; Ig: Immunoglobulin; TM: Transmembrane; DAP12: DNAx-activating protein 12 kDa; MYD88: Myeloid differentiation factor 88; SYK: Spleen tyrosine kinase; ZAP70: Zeta chain-associated protein kinase 70; IRAK1: Interleukin 1 receptor associated kinase 1; TRAF: Tumor necrosis factor receptor-associated factor; TAK1: Transforming growth factor-beta-activated kinase 1; TAB: Transforming growth factor-beta-activated kinase 1-associated binding protein; ERK: Extracellular signal-regulated kinase; RIP2: Receptor-interacting protein 2; CARD9: Caspase recruitment domain family member 9; GRB2: Growth factor receptor bound protein 2; SOS: Son of sevenless; PI3K: Phosphoinositide 3-kinases; AKT: Protein kinase B; PLC: Phosphatidylinositol-specific phospholipase C; IKK: I-κB kinase; NF-κB: Nuclear factor κB; CREB: Cyclic adenosine monophosphate reactive element binding protein; HMGB1: High mobility group protein 1; PGLYRP1: Peptidoglycan recognition protein 1; HSP70: Heat shock 70 kDa protein; eCIRP: Extracellular cold-inducible RNA-binding protein; TLR4: Toll-like receptor 4; ROS: Reactive oxygen species; PKC: Protein kinase C; NLRP3: NLR family pyrin domain containing 3; MAPK: Mitogen-activated protein kinase; MMP9: Matrix metallopeptidase 9; ZO-1: Zonula occludens-1; BBB: Blood-brain barrier.