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World J Clin Cases. Mar 26, 2025; 13(9): 100312
Published online Mar 26, 2025. doi: 10.12998/wjcc.v13.i9.100312
Role of triggering receptor expressed on myeloid cells 1/2 in secondary injury after cerebral hemorrhage
Fan Yi, Hao Wu, Hai-Kang Zhao
Fan Yi, Hao Wu, Xi’an Medical University, Xi’an 710021, Shaanxi Province, China
Hao Wu, Hai-Kang Zhao, Department of Neurosurgery, The Second Affiliated Hospital of Xi’an Medical University, Xi’an 710038, Shaanxi Province, China
Co-corresponding authors: Hao Wu and Hai-Kang Zhao.
Author contributions: Yi F and Wu H designed the work and performed the acquisition analysis; Wu H interpreted the data; Wu H and Zhao HK created the new software, drafted and revised the manuscript, they contributed equally to the work as co-corresponding authors; and all the authors read and approved the final manuscript.
Supported by Shanxi Provincial Key Research and Development Plan Project, No. 2020ZDLSF01-02; and Doctor Foundation of the Second Affiliated Hospital of Xi’an Medical University, No. X2Y-R11.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Kang Zhao, Chief Physician, MD, PhD, Department of Neurosurgery, The Second Affiliated Hospital of Xi’an Medical University, No. 167 Fangdong Street, Baqiao District, Xi’an 710038, Shaanxi Province, China. xmu2neurosurgery@163.com
Received: August 13, 2024
Revised: October 26, 2024
Accepted: November 27, 2024
Published online: March 26, 2025
Processing time: 120 Days and 22.5 Hours
Core Tip

Core Tip: Based on the analysis of relevant research results in basic and clinical trials, this paper shows that inhibition of triggering receptor expressed on myeloid cells 1 and activation of triggering receptor expressed on myeloid cells 2 can alleviate neuroinflammatory immune response, and can significantly improve the long-term prognosis of neurological function in patients with cerebral hemorrhage, and significantly improve the ability of patients to live independently in daily life.