Hepatobiliary system and intestinal injury in new coronavirus infection (COVID-19): A retrospective study

Figure 1 Correlation matrix of interdependence of a number of indicators of the intestinal microbiota (presented horizontally, in columns from B to P) and the most frequently used clinical and biochemical indicators (in rows from 2 to 44). Correlation values are presented as absolute values, their strength is determined by both the value of the indicated values and the color intensity. In this case, direct correlation has shades of red, inverse correlation has shades of blue and a negative value. The main indicators of the intestinal microbiota were in a rather weak direct (from 0.023 to 0.229) and inverse (from -0.012 to -0.274) interdependence. However, as shown by a detailed analysis of the results presented in the table, in particular, lines No. 41-43, a significant dependence of a number of microbiota indicators was discovered on the content of fibrinogen (line 41), thrombin time (line 42), the content of antithrombin-III (line 43). It was found that the most significant inverse correlation was observed between the content of antithrombin-III and the number of fungi (-0.611), the number of lactobacilli (-0.569), the number of aerobes in the small intestine (-0.569). Moreover, a direct correlation was established (0.555) between the content of antithrombin-III and the ratio of anaerobic flora to aerobic.