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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Hepatobiliary system and intestinal injury in new coronavirus infection (COVID-19): A retrospective study
Konstantin V Kozlov, Konstantin V Zhdanov, Anna K Ratnikova, Vyacheslav A Ratnikov, Artem V Tishkov, Vladimir Grinevich, Yuriy A Kravchuk, Panteley I Miklush, Polina O Nikiforova, Vera V Gordienko, Alexander F Popov, Boris G Andryukov
Konstantin V Kozlov, Konstantin V Zhdanov, Yuriy A Kravchuk, Panteley I Miklush, Polina O Nikiforova, Vera V Gordienko, Department of Infectious Disease, Military Medical Academy Named After SM. Kirov, Saint-Petersburg 194044, Russia
Anna K Ratnikova, Department of Admission, Federal State Budgetary Institution "North-West District Scientific and Clinical Center Named After LG. Sokolov Federal Medical and Biological Agency", Saint-Petersburg 194291, Russia
Vyacheslav A Ratnikov, Department of Roentgenology, Federal State Budgetary Institution "North-West District Scientific and Clinical Center Named After LG. Sokolov Federal Medical and Biological Agency", Saint-Petersburg 194291, Russia
Artem V Tishkov, Department of Physics, Mathematics and Informatics, FSBEI HE IP. Pavlov SPbSMU MOH Russia, Saint-Petersburg 197022, Russia
Vladimir Grinevich, 2nd Department of Therapy (Advanced Medical Education), Military Medical Academy Named After SM. Kirov, Saint-Petersburg 194044, Russia
Alexander F Popov, Boris G Andryukov, School of Medicine, Far Eastern Federal University, Vladivostok 690922, Russia
Author contributions: Kozlov KV, Zhdanov KV, Ratnikova AK, Ratnikov VA, Tishkov AV, Grinevich V, Kravchuk YA, Miklush PI, Nikiforova PO, Gordienko VV, Popov AF, Andryukov BG wrote the manuscript, reviewed and agreed to the final version of the manuscript.
Institutional review board statement: The present study was reviewed and approved by the independent ethics committee of the Military Medical Academy named after SM. Kirov, protocol (Approval No. 246).
Informed consent statement: Informed written consent was obtained from the patient and her family for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Vera V Gordienko, MD, Doctor, Teacher, Department of Infectious Disease, Military Medical Academy named after S.M. Kirov, No. 6 Lebedeva Street, Saint-Petersburg 194044, Russia.
ivanovavmeda@gmail.com
Received: September 29, 2022
Peer-review started: September 29, 2022
First decision: January 3, 2023
Revised: January 22, 2023
Accepted: March 6, 2023
Article in press: March 6, 2023
Published online: April 6, 2023
Processing time: 181 Days and 15.2 Hours
BACKGROUND
An important area of effective control of the coronavirus disease 19 (COVID-19) pandemic is the study of the pathogenic features of severe acute respiratory syndrome coronavirus 2 infection, including those based on assessing the state of the intestinal microbiota and permeability.
AIM
To study the clinical features of the new COVID-19 in patients with mild and moderate severity at the stage of hospitalization, to determine the role of hepatobiliary injury, intestinal permeability disorders, and changes in the qualitative and quantitative composition of the microbiota in the development of systemic inflammation in patients with COVID-19.
METHODS
The study was performed in 80 patients with COVID-19, with an average age of 45 years, 19 of whom had mild disease, and 61 had moderate disease severity. The scope of the examination included traditional clinical, laboratory, biochemical, instrumental, and radiation studies, as well as original methods for studying microbiota and intestinal permeability.
RESULTS
The clinical course of COVID-19 was studied, and the clinical and biochemical features, manifestations of systemic inflammation, and intestinal microbiome changes in patients with mild and moderate severity were identified. Intestinal permeability characteristics against the background of COVID-19 were evaluated by measuring levels of proinflammatory cytokines, insulin, faecal calprotectin, and zonulin.
CONCLUSION
This study highlights the role of intestinal permeability and microbiota as the main drivers of gastroenterological manifestations and increased COVID-19 severity.
Core Tip: The clinical course of coronavirus disease 19 (COVID-19) was studied, and the clinical and biochemical features, manifestations of systemic inflammation, and intestinal microbiome changes in patients with mild and moderate severity were identified. Intestinal permeability characteristics against the background of COVID-19 were evaluated by measuring levels of proinflammatory cytokines, insulin, faecal calprotectin, and zonulin. This study highlights the role of intestinal permeability and microbiota as the main drivers of gastroenterological manifestations and increased COVID-19 severity.
