Case Report
Copyright ©The Author(s) 2022.
World J Clin Cases. Jun 6, 2022; 10(16): 5502-5509
Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5502
Figure 1
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Figure 1 Endoscopic images. A and B: An ulcerative tumor was approximately 1-3 cm away from the esophagogastric junction.
Figure 2
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Figure 2 Computed tomography images. A: Uneven thickening of the lesser curvature of the cardia and corpus, in accordance with gastric cancer; B: Coalesced lymph nodes in cardiac area, approximately 0.8 cm in diameter.
Figure 3
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Figure 3 Histological findings of the primary lesion. A: Mixed large and small cell neuroendocrine carcinoma of the stomach [hematoxylin-eosin (HE), × 100]. The pictures show large cell neuroendocrine carcinoma on the left side (orange arrow) and small cell neuroendocrine carcinoma on the right side (green arrow); B: The two components were separated clearly. Large cell neuroendocrine carcinoma (HE, × 400); C: Small cell neuroendocrine carcinoma (HE, × 400).
Figure 4
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Figure 4 Histological findings of metastatic lymph nodes. A and B: Metastatic lymph node with large cell neuroendocrine carcinoma [A, hematoxylin-eosin (HE), × 100; B, HE, × 400]; C and D: Metastatic lymph node with small cell neuroendocrine carcinoma (C, HE, × 200; D, HE, × 400); E and F: Metastatic lymph node with mixed large and small cell neuroendocrine carcinoma. The orange arrow points to large cell neuroendocrine carcinoma, and the green arrow points to small cell neuroendocrine carcinoma (E, HE, × 100; F, HE, × 200); G: Large cell neuroendocrine carcinoma components of mixed large and small cell neuroendocrine carcinoma lymph nodes (HE, × 400); H: Small cell neuroendocrine carcinoma components of mixed large and small cell neuroendocrine carcinoma lymph nodes (HE, × 400).
Figure 5
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Figure 5 Histological findings and immunohistochemical staining. A-E: Large cell neuroendocrine carcinoma [A, hematoxylin-eosin (HE), × 200] showed positive immunohistochemical staining for chromogranin A (B, × 200), synaptophysin (C, × 200) and P53 (D, × 200). The Ki-67 index was approximately 60% (E, × 200); F-J: Small cell neuroendocrine carcinoma (F, HE, × 400) showed positive immunohistochemical staining for chromogranin A (G, × 200), synaptophysin (H, × 200) and P53 (I, × 200). The Ki-67 index was approximately 60% (J, × 200).