Wang H, Fu YX, Song WL, Wang Z, Feng G, Zhao J, Nian YQ, Cao Y. Human parvovirus B19-associated early postoperative acquired pure red cell aplasia in simultaneous pancreas-kidney transplantation: A case report. World J Clin Cases 2021; 9(8): 1968-1975 [PMID: 33748248 DOI: 10.12998/wjcc.v9.i8.1968]
Corresponding Author of This Article
Ying-Xin Fu, MD, PhD, Chief Doctor, Professor, Surgeon, Department of Kidney and Pancreas Transplant, Tianjin First Central Hospital, School of Medicine, Nankai University, No. 24 Fukang Road, Nankai District, Tianjin 300192, China. fuyingxintj@163.com
Research Domain of This Article
Transplantation
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 16, 2021; 9(8): 1968-1975 Published online Mar 16, 2021. doi: 10.12998/wjcc.v9.i8.1968
Human parvovirus B19-associated early postoperative acquired pure red cell aplasia in simultaneous pancreas-kidney transplantation: A case report
Hui Wang, Ying-Xin Fu, Wen-Li Song, Zhen Wang, Gang Feng, Jie Zhao, Ye-Qi Nian, Yu Cao
Hui Wang, Ying-Xin Fu, Wen-Li Song, Zhen Wang, Gang Feng, Jie Zhao, Ye-Qi Nian, Yu Cao, Department of Kidney and Pancreas Transplant, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China
Author contributions: Wang H summarized the clinical data, and drafted the manuscript; Fu YX contributed to the conception of the study; Song WL, Wang Z, Feng G and Zhao J performed the transplant surgery; Nian YQ and Cao Y summarized the clinical data and analyzed the data.
Supported byNational Natural Science Foundation of , No. 81970654.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying-Xin Fu, MD, PhD, Chief Doctor, Professor, Surgeon, Department of Kidney and Pancreas Transplant, Tianjin First Central Hospital, School of Medicine, Nankai University, No. 24 Fukang Road, Nankai District, Tianjin 300192, China. fuyingxintj@163.com
Received: November 5, 2020 Peer-review started: November 5, 2020 First decision: December 24, 2020 Revised: December 30, 2020 Accepted: January 22, 2021 Article in press: January 22, 2021 Published online: March 16, 2021 Processing time: 120 Days and 3.6 Hours
Core Tip
Core Tip: This study presents a patient who developed human parvovirus (HPV) B19-associated acquired pure red cell aplasia (aPRCA) in the early postoperative period following simultaneous pancreas-kidney transplantation. Metagenomic next-generation sequencing (mNGS) was used to diagnose HPV B19 infection and the diminution in mNGS reads was correlated with hemoglobin and reticulocyte count improvements. Effective therapy included intravenous immunoglobulin infusion and adjustment of the immunosuppressive regimen. HPV B19-associated aPRCA should be considered when a patient experiences erythropoietin-resistant anemia and reticulocytopenia in the early postoperative period. Moreover, mNGS could be used for diagnosis and to reflect disease progression.
