Case Control Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2021; 9(7): 1524-1531
Published online Mar 6, 2021. doi: 10.12998/wjcc.v9.i7.1524
Efficacy and safety of short duration radiotherapy combined with chemotherapy for advanced rectal cancer
Shu-Quan Gao, Ying-Chun Zhang, Chao Zhang, Sheng-Jie Wang, Wei Ren, Na Yuan, Jun-Ye Wen
Shu-Quan Gao, Ying-Chun Zhang, Sheng-Jie Wang, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075061, Hebei Province, China
Chao Zhang, Department of Interventional Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075061, Hebei Province, China
Wei Ren, Operating Room, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075061, Hebei Province, China
Na Yuan, Department of Radiotherapy, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075061, Hebei Province, China
Jun-Ye Wen, Department of General Surgery, Hebei Provincial People’s Hospital, Shijiazhuang 050003, Hebei Province, China
Author contributions: Gao SQ and Zhang YC designed the study; Gao SQ, Zhang YC, Zhang C, Wang SJ, Ren W, Yuan N and Wen JY collected the data and materials as well as analyzed the data; all authors wrote the manuscript; Gao SQ and Zhang YC reviewed the manuscript; All authors approved the final version of the manuscript.
Supported by The Key Science and Technology Program of Zhangjiakou, No. 1921132H.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the First Affiliated Hospital of Hebei North University.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: No conflict of interest for all authors.
Data sharing statement: No additional to be shared.
STROBE statement: The authors have read the STROBE Statement checklist of items, and the manuscript was revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying-Chun Zhang, MSc, Associate Chief Physician, Associate Professor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Qiaoxi District, Zhangjiakou 075061, Hebei Province, China. zhyingchun@sina.cn
Received: December 3, 2020
Peer-review started: December 3, 2020
First decision: December 13, 2020
Revised: December 28, 2020
Accepted: January 15, 2021
Article in press: January 15, 2021
Published online: March 6, 2021
Processing time: 87 Days and 18.1 Hours
Core Tip

Core Tip: Short duration radiotherapy was compared to conventional fractionated radiation treatment plus chemotherapy in 100 patients with stage IIIB or more severe rectal cancer to verify whether short duration preoperative radiotherapy had an advantage in diminishing complications, reducing risk of recurrence and improving survival. The findings revealed that there was no significant difference in the incidence of complications between short and long duration radiotherapy plus chemotherapy. However, short duration radiotherapy improved the 1-yr survival rate and reduced the recurrence rate and distant metastasis rate in comparison with conventional preoperative radiotherapy.