Observational Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 26, 2021; 9(6): 1318-1328
Published online Feb 26, 2021. doi: 10.12998/wjcc.v9.i6.1318
Impact of metabolism-related mutations on the heart rate of gastric cancer patients after peritoneal lavage
Yan Yuan, Shuang Yao, Guang-Hua Luo, Xiao-Ying Zhang
Yan Yuan, Department of Anesthesiology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China
Shuang Yao, Guang-Hua Luo, Comprehensive Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China
Xiao-Ying Zhang, Department of Cardio-Thoracic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China
Author contributions: Yuan Y and Zhang XY conceived and supervised the study; Luo GH and Yao S designed the experiments; Yuan Y, Yao S and Luo GH performed the experiments; Luo GH provided new tools and reagents; Luo GH developed new software and performed simulation studies; Yuan Y and Luo GH analyzed data; Yuan Y, Yao S and Luo GH wrote the manuscript; Luo GH and Zhang XY revised the manuscript; all authors reviewed the results and approved the final version of the manuscript.
Institutional review board statement: The study was approved by the ethics committee of the Third Affiliated Hospital of Soochow University.
Informed consent statement: All participants signed an informed consent form.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Ying Zhang, Chief Cardiac Surgeon, Professor, Surgeon, Department of Cardio-Thoracic Surgery, The Third Affiliated Hospital of Soochow University, No. 185 Juqian Street, Tianning District, Changzhou 213003, Jiangsu Province, China. zhangxy6689996@163.com
Received: September 14, 2020
Peer-review started: September 14, 2020
First decision: November 23, 2020
Revised: December 4, 2020
Accepted: December 16, 2020
Article in press: December 16, 2020
Published online: February 26, 2021
Processing time: 144 Days and 22.6 Hours
Core Tip

Core Tip: Haplotype analysis suggested that the haplotypes CTT and GCC of TEP1, TEP1, and RECQL5 increased the risk of a drop in heart rate > 30%. The TEP1 (rs938886), TEP1 (rs1713449), and RECQL5 (rs820196) single nucleotide polymorphisms were associated with changes in heart rate ≥ 30% during intraperitoneal lavage using distilled water after gastrectomy for gastric cancer.