Published online Feb 26, 2021. doi: 10.12998/wjcc.v9.i6.1318
Peer-review started: September 14, 2020
First decision: November 23, 2020
Revised: December 4, 2020
Accepted: December 16, 2020
Article in press: December 16, 2020
Published online: February 26, 2021
Processing time: 144 Days and 22.6 Hours
For the first time, we found that severe cardiovascular changes occurred in patients with gastric cancer during intraoperative distilled water lavage, which was also observed in a large cohort.
The internal causes of this phenomenon were studied through detailed clinical case observation and a mechanistic study.
The target population was screened out through gene detection and verification.
We conducted a prospective observational study of the included cases, and selected typical patients for gene screening, and the results were validated in a large cohort.
We successfully validated a site mutation in TEP1-886, TEP1-449 as well as RECQL5, and selected the heart rate change of 30% as the cut-off value for comparison and regression analysis.
SNPs in TEP1 (rs938886), TEP1 (rs1713449) and RECQL5 (rs820196) were associated with changes in heart rate > 30% when peritoneal lavage with distilled water was performed after gastrectomy for gastric cancer patients.
We performed pre-operative detection of TEP1 and RECQL5 genes in patients and selected different lavage methods for high-risk groups to improve peri-operative safety.