Published online Feb 26, 2021. doi: 10.12998/wjcc.v9.i6.1318
Peer-review started: September 14, 2020
First decision: November 23, 2020
Revised: December 4, 2020
Accepted: December 16, 2020
Article in press: December 16, 2020
Published online: February 26, 2021
For the first time, we found that severe cardiovascular changes occurred in patients with gastric cancer during intraoperative distilled water lavage, which was also observed in a large cohort.
The internal causes of this phenomenon were studied through detailed clinical case observation and a mechanistic study.
The target population was screened out through gene detection and verification.
We conducted a prospective observational study of the included cases, and selected typical patients for gene screening, and the results were validated in a large cohort.
We successfully validated a site mutation in TEP1-886, TEP1-449 as well as RECQL5, and selected the heart rate change of 30% as the cut-off value for comparison and regression analysis.
SNPs in TEP1 (rs938886), TEP1 (rs1713449) and RECQL5 (rs820196) were associated with changes in heart rate > 30% when peritoneal lavage with distilled water was performed after gastrectomy for gastric cancer patients.
We performed pre-operative detection of TEP1 and RECQL5 genes in patients and selected different lavage methods for high-risk groups to improve peri-operative safety.