Yuan Y, Yao S, Luo GH, Zhang XY. Impact of metabolism-related mutations on the heart rate of gastric cancer patients after peritoneal lavage. World J Clin Cases 2021; 9(6): 1318-1328 [PMID: 33644198 DOI: 10.12998/wjcc.v9.i6.1318]
Corresponding Author of This Article
Xiao-Ying Zhang, Chief Cardiac Surgeon, Professor, Surgeon, Department of Cardio-Thoracic Surgery, The Third Affiliated Hospital of Soochow University, No. 185 Juqian Street, Tianning District, Changzhou 213003, Jiangsu Province, China. zhangxy6689996@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 26, 2021; 9(6): 1318-1328 Published online Feb 26, 2021. doi: 10.12998/wjcc.v9.i6.1318
Impact of metabolism-related mutations on the heart rate of gastric cancer patients after peritoneal lavage
Yan Yuan, Shuang Yao, Guang-Hua Luo, Xiao-Ying Zhang
Yan Yuan, Department of Anesthesiology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China
Shuang Yao, Guang-Hua Luo, Comprehensive Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China
Xiao-Ying Zhang, Department of Cardio-Thoracic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China
Author contributions: Yuan Y and Zhang XY conceived and supervised the study; Luo GH and Yao S designed the experiments; Yuan Y, Yao S and Luo GH performed the experiments; Luo GH provided new tools and reagents; Luo GH developed new software and performed simulation studies; Yuan Y and Luo GH analyzed data; Yuan Y, Yao S and Luo GH wrote the manuscript; Luo GH and Zhang XY revised the manuscript; all authors reviewed the results and approved the final version of the manuscript.
Institutional review board statement: The study was approved by the ethics committee of the Third Affiliated Hospital of Soochow University.
Informed consent statement: All participants signed an informed consent form.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Ying Zhang, Chief Cardiac Surgeon, Professor, Surgeon, Department of Cardio-Thoracic Surgery, The Third Affiliated Hospital of Soochow University, No. 185 Juqian Street, Tianning District, Changzhou 213003, Jiangsu Province, China. zhangxy6689996@163.com
Received: September 14, 2020 Peer-review started: September 14, 2020 First decision: November 23, 2020 Revised: December 4, 2020 Accepted: December 16, 2020 Article in press: December 16, 2020 Published online: February 26, 2021 Processing time: 144 Days and 22.6 Hours
ARTICLE HIGHLIGHTS
Research background
For the first time, we found that severe cardiovascular changes occurred in patients with gastric cancer during intraoperative distilled water lavage, which was also observed in a large cohort.
Research motivation
The internal causes of this phenomenon were studied through detailed clinical case observation and a mechanistic study.
Research objectives
The target population was screened out through gene detection and verification.
Research methods
We conducted a prospective observational study of the included cases, and selected typical patients for gene screening, and the results were validated in a large cohort.
Research results
We successfully validated a site mutation in TEP1-886, TEP1-449 as well as RECQL5, and selected the heart rate change of 30% as the cut-off value for comparison and regression analysis.
Research conclusions
SNPs in TEP1 (rs938886), TEP1 (rs1713449) and RECQL5 (rs820196) were associated with changes in heart rate > 30% when peritoneal lavage with distilled water was performed after gastrectomy for gastric cancer patients.
Research perspectives
We performed pre-operative detection of TEP1 and RECQL5 genes in patients and selected different lavage methods for high-risk groups to improve peri-operative safety.
