Systematic Reviews
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 6, 2021; 9(34): 10616-10625
Published online Dec 6, 2021. doi: 10.12998/wjcc.v9.i34.10616
Effects of hypoxia on bone metabolism and anemia in patients with chronic kidney disease
Chao Kan, Xu Lu, Rui Zhang
Chao Kan, Xu Lu, Department of Clinical Medicine, Changchun University of Chinese Medicine, Changchun 130000, Jilin Province, China
Rui Zhang, Department of Nephrology, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai 519070, Guangdong Province, China
Author contributions: Zhang R initiated the project and gave constructive comments and suggestions for the manuscript; Kan C drafted the manuscript; Lu X provided assistance with the figures and tables; and all authors have read and approved the manuscript.
Conflict-of-interest statement: The authors declare that they have no competing interests to disclose.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rui Zhang, PhD, Chief Physician, Department of Nephrology, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University), No. 79 Kangning Road, Xiangzhou District, Zhuhai 519070, Guangdong Province, China. zhangruidoctor@163.com
Received: May 7, 2021
Peer-review started: May 7, 2021
First decision: July 26, 2021
Revised: August 12, 2021
Accepted: October 25, 2021
Article in press: October 25, 2021
Published online: December 6, 2021
Core Tip

Core Tip: Anemia and abnormal bone metabolism are complications in patients with chronic kidney disease (CKD), which seriously affect the prognosis of patients. This review summarizes the findings from recent studies on renal anemia and abnormal bone metabolism in patients with CKD. The bidirectional relationship between anemia and abnormal bone metabolism in patients with CKD is discussed. While studying the treatment of anemia with hypoxia-inducible factor (HIF), it was found that hypoxia can affect bone metabolism, but there is no consensus on the efficacy of HIF stabilizers in renal bone disease.