Published online Dec 6, 2021. doi: 10.12998/wjcc.v9.i34.10616
Peer-review started: May 7, 2021
First decision: July 26, 2021
Revised: August 12, 2021
Accepted: October 25, 2021
Article in press: October 25, 2021
Published online: December 6, 2021
Abnormal bone metabolism and renal anemia seriously affect the prognosis of patients with chronic kidney disease (CKD). Existing studies have mostly addressed the pathogenesis and treatment of bone metabolism abnormality and anemia in patients with CKD, but few have evaluated their mutual connection. Administration of exogenous erythropoietin to CKD patients with anemia used to be the mainstay of therapeutic approaches; however, with the availability of hypoxia-inducible factor (HIF) stabilizers such as roxadustat, more therapeutic choices for renal anemia are expected in the future. However, the effects posed by the hypoxic environment on both CKD complications remain incompletely understood.
To summarize the relationship between renal anemia and abnormal bone metabolism, and to discuss the influence of hypoxia on bone metabolism.
CNKI and PubMed searches were performed using the key words “chronic kidney disease,” “abnormal bone metabolism,” “anemia,” “hypoxia,” and “HIF” to identify relevant articles published in multiple languages and fields. Reference lists from identified articles were reviewed to extract additional pertinent articles. Then we retrieved the Abstract and Introduction and searched the results from the literature, classified the extracted information, and summarized important information. Finally, we made our own conclusions.
There is a bidirectional relationship between renal anemia and abnormal bone metabolism. Abnormal vitamin D metabolism and hyperparathyroidism can affect bone metabolism, blood cell production, and survival rates through mul
There is a bidirectional relationship between renal anemia and abnormal bone metabolism. Hypoxia may improve bone metabolism but the concentration and duration of hypoxia remain unclear and need further study.
Core Tip: Anemia and abnormal bone metabolism are complications in patients with chronic kidney disease (CKD), which seriously affect the prognosis of patients. This review summarizes the findings from recent studies on renal anemia and abnormal bone metabolism in patients with CKD. The bidirectional relationship between anemia and abnormal bone metabolism in patients with CKD is discussed. While studying the treatment of anemia with hypoxia-inducible factor (HIF), it was found that hypoxia can affect bone metabolism, but there is no consensus on the efficacy of HIF stabilizers in renal bone disease.