Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2021; 9(33): 10355-10361
Published online Nov 26, 2021. doi: 10.12998/wjcc.v9.i33.10355
Persistent fibrinogen deficiency after snake bite: A case report
Meng-Hao Xu, Jing Li, Liang Han, Chao Chen
Meng-Hao Xu, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Jing Li, Liang Han, Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Chao Chen, Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Chao Chen, Department of Orthopaedics, Hefeng Central Hospital, Enshi 445800, Hubei Province, China
Author contributions: Xu MH and Chen C designed the research study; Xu MH, Li J and Han L performed the research; Xu MH, Li J and Chen C analyzed the data and wrote the manuscript; all authors have read and approve the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chao Chen, MD, PhD, Doctor, Research Fellow, Surgeon, Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. chenchao027@163.com
Received: July 8, 2021
Peer-review started: July 8, 2021
First decision: July 26, 2021
Revised: July 30, 2021
Accepted: September 8, 2021
Article in press: September 8, 2021
Published online: November 26, 2021
Processing time: 136 Days and 19.4 Hours
Core Tip

Core Tip: Venom-induced consumption coagulopathy (VICC) is characterized by decreased coagulation factor activity and fibrinogen (FBG) deficiency. Hemorrhage-inducing snake venom contains several ingredients that directly or indirectly consume fibrinogen through multiple mechanisms. We report a rare case with persistent afibrinogenemia without abnormal coagulation factor activity after snake bite. Our report may assist the diagnosis and treatment of FBG deficiency in patients with VICC.