Retrospective Cohort Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2021; 9(33): 10075-10087
Published online Nov 26, 2021. doi: 10.12998/wjcc.v9.i33.10075
Utility of cooling patches to prevent hand-foot syndrome caused by pegylated liposomal doxorubicin in breast cancer patients
Yan-Fu Zheng, Xin Fu, Xiao-Xu Wang, Xiao-Jing Sun, Xiao-Dan He
Yan-Fu Zheng, Xin Fu, Xiao-Xu Wang, Xiao-Jing Sun, Department of Breast Oncology, Cancer Hospital of China Medical University (Liaoning Cancer Hospital and Institute), Shenyang 110042, Liaoning Province, China
Xiao-Dan He, Department of Gynecology, Cancer Hospital of China Medical University (Liaoning Cancer Hospital and Institute), Shenyang 110042, Liaoning Province, China
Author contributions: Zheng YF, Fu X, Wang XX, Sun XJ, and He XD contributed to the writing and revising of the manuscript; and all the authors have read and approved the final version to be submitted.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Liaoning Cancer Hospital and Institute Institutional Review Board (Approval No. 20210644).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: Each author certifies that he or she has not received any fees for serving as a speaker or server as a member of any organization. None of the authors owns a patent.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at ella99123@163.com. Participants gave informed consent for data sharing.
STROBE statement: The manuscript has been checked according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin Fu, BSc, RN, Chief Nurse, Department of Breast Oncology, Cancer Hospital of China Medical University (Liaoning Cancer Hospital and Institute), No. 44 Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China. ella99123@163.com
Received: July 19, 2021
Peer-review started: July 19, 2021
First decision: August 19, 2021
Revised: September 1, 2021
Accepted: September 22, 2021
Article in press: September 22, 2021
Published online: November 26, 2021
Core Tip

Core Tip: The significance of cooling patches to prevent hand-foot syndrome (HFS) caused by pegylated liposomal doxorubicin (PLD) in breast cancer patients was evaluated. We retrospectively analyzed 101 breast cancer patients treated with PLD. Fifty-one patients applied cooling patches to their hands (the cooling group), and fifty patients did not apply cooling patches (the control group). We observed and recorded the occurrence of HFS. In the short-term, patients in the cooling group had a lower incidence of HFS than those in the control group (40% vs 2%), and patients' self-efficacy in the cooling group decreased more slowly than that in the control group, and the difference was statistically significant.