Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2021; 9(33): 10052-10063
Published online Nov 26, 2021. doi: 10.12998/wjcc.v9.i33.10052
Effects of alcohol consumption on viral hepatitis B and C
Hong-Qin Xu, Chun-Guang Wang, Qiang Zhou, Yan-Hang Gao
Hong-Qin Xu, Qiang Zhou, Yan-Hang Gao, Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin Province, China
Chun-Guang Wang, Department of Surgery, The Second Hospital of Jilin University, Jilin University, Changchun 130041, Jilin Province, China
Author contributions: Xu HQ wrote the paper; Wang CG, Zhou Q, and Gao YH edited the manuscript; Gao YH is corresponding author; All authors contributed important intellectual content during manuscript drafting or revision and accepts accountability for the overall work by ensuring that questions pertaining to the accuracy or integrity of any portion of the work are appropriately investigated and resolved.
Supported by the National Natural Science Foundation of China, No. 81972265; the National Key Research Plan "Precision Medicine Research" Key Project, No. 2017YFC0908103 and No. 2017YFC0908104; the National Science and Technology Major Project, No. 2017ZX10202202 and No. 2018ZX10302206; the National Natural Science Foundation of Jilin Province, No. 20200201324JC and No. 20200201532JC; and Program for JLU Science and Technology Innovative Research Team, No. 2017TD-08.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Hang Gao, PhD, Chief Doctor, Professor, Department of Hepatology, The First Hospital of Jilin University, Jilin University, No. 71 Xinmin Street, Changchun 130021, Jilin Province, China. yanhang@mail.jlu.edu.cn
Received: February 19, 2021
Peer-review started: February 19, 2021
First decision: March 28, 2021
Revised: April 15, 2021
Accepted: August 25, 2021
Article in press: August 25, 2021
Published online: November 26, 2021
Core Tip

Core Tip: (1) Alcohol adversely affects hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in the liver via promoting viral replication, increasing oxidative stress, suppressing the viral immune responses, etc.; (2) The interaction of alcohol with viral hepatitis contributes to an increased risk of developing HBV- or HCV-induced liver fibrosis, end-stage cirrhosis, and even deadly liver cancer; and (3) Individuals with HBV or HCV infection should abstain from alcohol to slow the disease progression.