Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2021; 9(31): 9549-9556
Published online Nov 6, 2021. doi: 10.12998/wjcc.v9.i31.9549
Malignant adenomyoepithelioma of the breast: Two case reports and review of the literature
Duan-Yang Zhai, Tian-Tian Zhen, Xiao-Ling Zhang, Jia Luo, Hui-Juan Shi, Ya-Wei Shi, Nan Shao
Duan-Yang Zhai, Ya-Wei Shi, Nan Shao, The Breast Disease Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510000, Guangdong Province, China
Tian-Tian Zhen, Hui-Juan Shi, Department of Pathology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510000, Guangdong Province, China
Xiao-Ling Zhang, Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510000, Guangdong Province, China
Jia Luo, Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510000, Guangdong Province, China
Author contributions: Zhai DY and Shao N guided the diagnosis and treatment of this case; Zhai DY and Zhen TT reviewed all the related literature and analyzed the clinical data; Zhen TT and Shi HJ provided the pathological diagnosis and figures; Luo J and Zhang XL assessed the imaging features; Zhai DY drafted the manuscript; Shi YW and Shao N critically revised the manuscript; All authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81902675; and the Medical Science and Technology Foundation of Guangdong, No. A2018069.
Informed consent statement: The study participants provided written informed consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nan Shao, MD, PhD, Professor, The Breast Disease Center, The First Affiliated Hospital of Sun Yat-Sen University, No. 58 Zhong Shan Er Lu, Guangzhou 510000, Guangdong Province, China. shaon@mail.sysu.edu.cn
Received: February 22, 2021
Peer-review started: February 22, 2021
First decision: July 15, 2021
Revised: July 27, 2021
Accepted: September 8, 2021
Article in press: September 8, 2021
Published online: November 6, 2021
Processing time: 249 Days and 5.8 Hours
Core Tip

Core Tip: This report describes malignant adenomyoepithelioma (AME) of the breast, a rare tumor, which is difficult to assess and prone to local relapse and metastasis. No mature clinical experiences are available for reference, and it is thus significant to report unusual cases to help scholars worldwide establish a systematic treatment regimen. We present the treatment process and disease characteristics of two patients in different departments, as well as a brief literature review to investigate the clinicopathological features, diagnosis, treatment, and prognosis of malignant breast AME.