Zhai DY, Zhen TT, Zhang XL, Luo J, Shi HJ, Shi YW, Shao N. Malignant adenomyoepithelioma of the breast: Two case reports and review of the literature. World J Clin Cases 2021; 9(31): 9549-9556 [PMID: 34877289 DOI: 10.12998/wjcc.v9.i31.9549]
Corresponding Author of This Article
Nan Shao, MD, PhD, Professor, The Breast Disease Center, The First Affiliated Hospital of Sun Yat-Sen University, No. 58 Zhong Shan Er Lu, Guangzhou 510000, Guangdong Province, China. shaon@mail.sysu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Duan-Yang Zhai, Ya-Wei Shi, Nan Shao, The Breast Disease Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510000, Guangdong Province, China
Tian-Tian Zhen, Hui-Juan Shi, Department of Pathology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510000, Guangdong Province, China
Xiao-Ling Zhang, Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510000, Guangdong Province, China
Jia Luo, Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510000, Guangdong Province, China
Author contributions: Zhai DY and Shao N guided the diagnosis and treatment of this case; Zhai DY and Zhen TT reviewed all the related literature and analyzed the clinical data; Zhen TT and Shi HJ provided the pathological diagnosis and figures; Luo J and Zhang XL assessed the imaging features; Zhai DY drafted the manuscript; Shi YW and Shao N critically revised the manuscript; All authors read and approved the final manuscript.
Supported byNational Natural Science Foundation of China, No. 81902675; and the Medical Science and Technology Foundation of Guangdong, No. A2018069.
Informed consent statement: The study participants provided written informed consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nan Shao, MD, PhD, Professor, The Breast Disease Center, The First Affiliated Hospital of Sun Yat-Sen University, No. 58 Zhong Shan Er Lu, Guangzhou 510000, Guangdong Province, China. shaon@mail.sysu.edu.cn
Received: February 22, 2021 Peer-review started: February 22, 2021 First decision: July 15, 2021 Revised: July 27, 2021 Accepted: September 8, 2021 Article in press: September 8, 2021 Published online: November 6, 2021 Processing time: 249 Days and 5.8 Hours
Abstract
BACKGROUND
Malignant adenomyoepithelioma (AME) of the breast is a rare tumor in which malignancy can arise from either epithelial or myoepithelial components, or from both cell types. The incidence and prognosis of malignant AME of the breast are difficult to assess due to its rarity. Therefore, the optimal treatment for this disease is still controversial.
CASE SUMMARY
We present two middle-aged women (48 and 56 years old) with malignant AME of the breast. Core needle biopsy was performed before surgery. However, breast adenoma and malignant tumors were observed. The preoperative diagnosis of malignant AME of the breast is still challenging for pathologists and clinicians. Both patients underwent mastectomy and sentinel lymph node biopsy, both of which were negative, followed by adjuvant chemotherapy.
CONCLUSION
The follow-up duration of the two patients was two years and four months, respectively. No signs of relapse or metastasis have been observed thus far.
Core Tip: This report describes malignant adenomyoepithelioma (AME) of the breast, a rare tumor, which is difficult to assess and prone to local relapse and metastasis. No mature clinical experiences are available for reference, and it is thus significant to report unusual cases to help scholars worldwide establish a systematic treatment regimen. We present the treatment process and disease characteristics of two patients in different departments, as well as a brief literature review to investigate the clinicopathological features, diagnosis, treatment, and prognosis of malignant breast AME.
