Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2021; 9(30): 9255-9268
Published online Oct 26, 2021. doi: 10.12998/wjcc.v9.i30.9255
Diagnosis and treatment of acute graft-versus-host disease after liver transplantation: Report of six cases
Min Tian, Yi Lyu, Bo Wang, Chang Liu, Liang Yu, Jian-Hua Shi, Xue-Min Liu, Xiao-Gang Zhang, Kun Guo, Yu Li, Liang-Shuo Hu
Min Tian, Yi Lyu, Bo Wang, Chang Liu, Liang Yu, Jian-Hua Shi, Xue-Min Liu, Xiao-Gang Zhang, Kun Guo, Yu Li, Liang-Shuo Hu, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Author contributions: Tian M, Shi JH, Guo K, Li Y and Hu LS prepared and collected the case data; Lyu Y, Wang B, Liu C, Liu XM, Yu L and Zhang XG analyzed the diagnosis and treatment of the case, and summarized the experience of diagnosis and treatment; Tian M reviewed the literature and was responsible for drafting the manuscript; and all authors gave final approval for the version to be submitted.
Supported by The National Natural Science Foundation of China, No. 81870445; Scientific Research Project of Military Healthcare, No. BZZ19J004.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bo Wang, MD, PhD, Chief Doctor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 West Yanta Road, Xi’an 710061, Shaanxi Province, China. bobwang75@sina.com
Received: May 27, 2021
Peer-review started: May 27, 2021
First decision: June 24, 2021
Revised: July 6, 2021
Accepted: September 16, 2021
Article in press: September 16, 2021
Published online: October 26, 2021
Core Tip

Core Tip: Acute graft-versus-host disease (aGVHD) is rare after liver transplantation (LT) with an incidence rate of 0.57% and the high mortality (up to 83.33%), which poses a critical challenge to our hospital. The diagnosis of aGVHD mainly depends on clinical symptoms, laboratory examinations especially donor T-lymphocytes chimerism analysis and histopathological. The larger the age distribution and the earlier the first symptoms, it is herald that the more rapid the progression in post-LT aGVHD. The most appear steroid-resistant in post-LT aGVHD. Thus, lower the dose of the corticosteroids, improved antibiotic stewardship, Particularly, gut microbial interventions and donor-targeted serotherapy may provide novel therapeutics.