Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2021; 9(30): 9236-9243
Published online Oct 26, 2021. doi: 10.12998/wjcc.v9.i30.9236
Diagnosis and treatment of primary pulmonary enteric adenocarcinoma: Report of Six cases
Ling-Fang Tu, Ling-Yan Sheng, Jian-Ying Zhou, Xue-Fen Wang, Yue-Hong Wang, Qian Shen, Yi-Hong Shen
Ling-Fang Tu, Ling-Yan Sheng, Jian-Ying Zhou, Xue-Fen Wang, Yue-Hong Wang, Qian Shen, Yi-Hong Shen, Department of Respiratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Tu LF and Shen YH helped get all the data of the cases from hospital; Sheng LY, Tu LF, Zhou JY, Wang XF, Wang YH, and Shen Q drafted the manuscript; Shen YH is the supervisor; all authors read and approved the final manuscript.
Supported by Medicine and Health Project of Zhejiang Province, China, No. 2018KY049.
Informed consent statement: Informed consent was obtained from the patients for publication of this report and accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest for this manuscript.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Hong Shen, MD, Chief Doctor, Department of Respiratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. drsyh@zju.edu.cn
Received: May 21, 2021
Peer-review started: May 21, 2021
First decision: June 15, 2021
Revised: June 28, 2021
Accepted: August 20, 2021
Article in press: August 20, 2021
Published online: October 26, 2021
Core Tip

Core Tip: Primary pulmonary enteric adenocarcinoma (PEAC) is a very rare subtype of invasive adenocarcinoma, and there have been no large studies on PEAC to date. All clinical data of six patients with confirmed PEAC from 2013 to 2018 were collected in this study, and data on the diagnosis, differential diagnosis, and treatment of PEAC are discussed combined with all the associated literature. Our findings highlight that positive results for CDX2 and CK7 play an important role in the diagnosis and differential diagnosis of PEAC, and immunotherapy or targeted therapy focused on KRAS needs to be further studied for the treatment of PEAC.