Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2021; 9(30): 9023-9037
Published online Oct 26, 2021. doi: 10.12998/wjcc.v9.i30.9023
Preliminary establishment of a spinal stability scoring system for multiple myeloma
Xing-Chen Yao, Xiang-Jun Shi, Zi-Yu Xu, Jie Tan, Yan-Zhe Wei, Lei Qi, Zi-Hao Zhou, Xin-Ru Du
Xing-Chen Yao, Zi-Yu Xu, Yan-Zhe Wei, Lei Qi, Zi-Hao Zhou, Xin-Ru Du, Department of Orthopedic, Beijing Chaoyang Hospital, Beijing 100020, China
Xiang-Jun Shi, Jie Tan, Department of Hematology, Beijing Chaoyang Hospital, Beijing 100020, China
Author contributions: Yao XC is the primary author and contributed to the drafting and revision of the manuscript; Xu ZY and Shi XJ contributed to the data collection and drafting of the manuscript; Tan J, Wei YZ, Zhou ZH and Qi L contributed to the data analysis and interpretation of the data; Du XR and Li LH contributed to the conception of the article and revision of the manuscript; All authors read and approved the final manuscript.
Institutional review board statement: Institutional review board approval of Beijing Chaoyang Hospital was obtained for this study.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work noncommercially, and license their derivative works on different terms, provided the original work is properly cited and the use is noncommercial. See: http://creativecommons.org/Licenses/bync/4.0/
Corresponding author: Xin-Ru Du, PhD, Professor, Department of Orthopedic, Beijing Chaoyang Hospital, Gongren Tiyuguan Nanlu No. 8, Beijing 100020, China. duxinru@163.com
Received: March 12, 2021
Peer-review started: March 12, 2021
First decision: July 16, 2021
Revised: July 26, 2021
Accepted: September 16, 2021
Article in press: September 16, 2021
Published online: October 26, 2021
Processing time: 223 Days and 1.8 Hours
Core Tip

Core Tip: Multiple myeloma (MM) is an incurable malignant plasma cell disorder that represents the most common primary malignant bone tumor. According to the 2010 Spine Oncology Study Group, spinal instability is defined as the loss of spinal integrity due to tumor growth, which is associated with motor-related pain and symptoms, progressive deformities, and/or impairments in neurological function under physiological loads. Many studies have validated this scoring system and applied it in clinical practice for diseases including primary spinal tumors, metastatic spinal tumors, and MM. However, MM is different from other primary and metastatic malignant tumors of the spine. Osteolytic destruction is the most common type of bone destruction in most MM patients; it commonly involves bone metastasis in multiple vertebral bodies, and is often accompanied by peripheral soft tissue masses and nerve compression symptoms. To some extent, Spinal Instability Neoplastic Score is not applicable to MM patients. Based on the disease characteristics of multiple myeloma, a simple and practical new method for evaluating spinal stability in individuals with multiple myeloma is proposed, and can be used for the clinical evaluation and intervention of multiple myeloma patients.