Ronderos D, Omar AMS, Abbas H, Makker J, Baiomi A, Sun H, Mantri N, Choi Y, Fortuzi K, Shin D, Patel H, Chilimuri S. Chronic hepatitis-C infection in COVID-19 patients is associated with in-hospital mortality. World J Clin Cases 2021; 9(29): 8749-8762 [PMID: 34734053 DOI: 10.12998/wjcc.v9.i29.8749]
Corresponding Author of This Article
Sridhar Chilimuri, MD, Chairman, Department of Internal Medicine, BronxCare Hospital Center, 1650 Grand Concourse, Bronx, NY 10457, United States. chilimuri@bronxcare.org
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Diana Ronderos, Haozhe Sun, Nikhitha Mantri, YongsuN Choi, Ked Fortuzi, Dongmin Shin, Sridhar Chilimuri, Department of Internal Medicine, BronxCare Hospital Center, Bronx, NY 10457, United States
Alaa Mabrouk Salem Omar, Department of Cardiology, Mount Sinai Morning Side, New York, NY 10023, United States
Hafsa Abbas, Jasbir Makker, Ahmed Baiomi, Harish Patel, Division of Gastroenterology, Department of Medicine, BronxCare Health System, Bronx, NY 10457, United States
Author contributions: Ronderos D and Omar AMS, have conceptualization the study, performed data analysis and wrote the manuscript; Abbas H, Makker J, Baiomi A, Mantri N, Choi, Y, Fortzuri D and Shin D contributed to data buildup and manuscript write-up and Pate; Chilimuri SC did study supervision and assisted in Manuscript write-up and revision.
Institutional review board statement: The study was reviewed and approved by the BronxCare Hospital Center Institutional Review Board.
Informed consent statement: This was a retrospective study and consent forms is waived.
Conflict-of-interest statement: Authors have nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sridhar Chilimuri, MD, Chairman, Department of Internal Medicine, BronxCare Hospital Center, 1650 Grand Concourse, Bronx, NY 10457, United States. chilimuri@bronxcare.org
Received: January 29, 2021 Peer-review started: January 29, 2021 First decision: May 2, 2021 Revised: May 20, 2021 Accepted: September 8, 2021 Article in press: September 8, 2021 Published online: October 16, 2021 Processing time: 259 Days and 5.1 Hours
Core Tip
Core Tip: In patients with coronavirus disease 2019 (COVID-19), history of hepatitis C infection accentuated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral virulence and is a strong predictor of in-hospital mortality irrespective of baseline comorbidities, laboratory parameters, or COVID-19-induced liver injury. History of hepatitis C infection (HCV) in these patients seems to add a cumulative mortality risk to any clinical or laboratory profile. The mechanisms involved may be related to extra hepatic effects of HCV leading to enhanced ACE-2/TMPRSS mechanisms of SARS-CoV-2 virus and subsequent endothelial dysfunction. The realization is important for better characterization of the disease and triage this sub-group as high risk for therapeutic or prophylactic measures like vaccines.
