Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2021; 9(27): 8164-8170
Published online Sep 26, 2021. doi: 10.12998/wjcc.v9.i27.8164
Streptococcal pneumonia-associated hemolytic uremic syndrome treated by T-antibody-negative plasma exchange in children: Two case reports
Xiu-Li Wang, Yue Du, Cheng-Guang Zhao, Yu-Bin Wu, Ni Yang, Liang Pei, Li-Jie Wang, Qiu-Shi Wang
Xiu-Li Wang, Yue Du, Cheng-Guang Zhao, Yu-Bin Wu, Ni Yang, Liang Pei, Li-Jie Wang, Qiu-Shi Wang, Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Qiu-Shi Wang, Department of Blood Transfusion, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Du Y and Wang QS designed the new treatment; Wang XL and Zhao CG analyzed the data and co-wrote the manuscript; Wu YB, Yang N, Pei L and Wang LJ cared for the patient; All authors read and approved the final manuscript.
Informed consent statement: Written consents were obtained from the parents of the patients for publication.
Conflict-of-interest statement: No financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yue Du, MD, Chief Doctor, Department of Pediatrics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. duy@sj-hospital.org
Received: April 26, 2021
Peer-review started: April 26, 2021
First decision: May 24, 2021
Revised: May 29, 2021
Accepted: July 28, 2021
Article in press: July 28, 2021
Published online: September 26, 2021
Processing time: 143 Days and 7.7 Hours
Core Tip

Core Tip: We present the cases of two pediatric patients with atypical hemolytic uremic syndrome associated with Streptococcus pneumoniae-hemolytic uremic syndrome that was successfully treated by T-antibody-negative plasma exchange. The patients were followed up for 2 years with normalization of all laboratory parameters, normal blood pressure and normal renal function.