Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 16, 2021; 9(23): 6867-6871
Published online Aug 16, 2021. doi: 10.12998/wjcc.v9.i23.6867
FGFR2-TSC22D1, a novel FGFR2 fusion gene identified in a patient with colorectal cancer: A case report
Xiao-Ming Kao, Xi Zhu, Jun-Ling Zhang, Shi-Qing Chen, Chao-Gang Fan
Xiao-Ming Kao, Xi Zhu, Research Institure of General Surgery, Jinling Hospital, Nanjing 210002, Jiangsu Province, China
Jun-Ling Zhang, Shi-Qing Chen, Department of Medical, 3D Medicines Inc., Shanghai 201114, China
Chao-Gang Fan, Department of General Surgery, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing 210002, Jiangsu Province, China
Author contributions: Fan CG performed the conception and design of the study; Kao XM and Zhu X performed the acquisition of clinical data; Zhang JL and Chen SQ performed the analysis and interpretation of the data; Fan CG and Kao XM performed the manuscript drafting and revision; all authors performed the final approval of the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: JZ and SC were employed by Shanghai 3D Medicines Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chao-Gang Fan, PhD, Chief Doctor, Department of General Surgery, The Affiliated BenQ Hospital of Nanjing Medical University, No. 71 Hexi Street, Jianye District, Nanjing 210002, Jiangsu Province, China. fancg2002@hotmail.com
Received: March 17, 2021
Peer-review started: March 17, 2021
First decision: April 4, 2021
Revised: April 13, 2021
Accepted: June 28, 2021
Article in press: June 28, 2021
Published online: August 16, 2021
Processing time: 141 Days and 5.2 Hours
Core Tip

Core Tip: A colorectal cancer patient had a novel FGFR2-TSC22D1 fusion which included exons 1-17 of FGFR2 and exons 3 of TSC22D1. This fusion contains FGFR2 kinase domain and coil coiled domains encoded by TSC22D1 exon 3, which might induce oncogenesis. Our case enriches the FGFR2 fusion spectrum. We believe that these novel findings have important implications in the strategy development of therapy for colorectal cancer.