Expression of caspase-3 and hypoxia inducible factor 1α in hepatocellular carcinoma complicated by hemorrhage and necrosis

doi:10.12998/wjcc.v9.i23.6725

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Aug 16, 2021; 9(23): 6725-6733
Published online Aug 16, 2021. doi: 10.12998/wjcc.v9.i23.6725

Expression of caspase-3 and hypoxia inducible factor 1α in hepatocellular carcinoma complicated by hemorrhage and necrosis

Hui Liang, Jian-Guo Wu, Fei Wang, Bo-Xuan Chen, Shi-Tian Zou, Cong Wang, Shuai-Wu Luo

Hui Liang, Fei Wang, Bo-Xuan Chen, Shi-Tian Zou, Cong Wang, Shuai-Wu Luo, Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China

Jian-Guo Wu, Department of Nuclear Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China

Author contributions: Liang H and Wu JG designed the study; Wang F drafted the work; Chen BX and Zou ST collected the data; Wang C analyzed and interpreted the data; Liang H and Luo SW wrote the article.

Supported by Research Project for Jiangxi Educational Department, No. 180086.

Institutional review board statement: This study was reviewed and approved by the Ethics Committee of The Second Affiliated Hospital of Nanchang University.

Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.

Conflict-of-interest statement: None.

Data sharing statement: No additional data are available.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Jian-Guo Wu, PhD, Chief Doctor, Department of Nuclear Medicine, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Donghu District, Nanchang 330006, Jiangxi Province, China. grantwu2021@163.com

Received: March 4, 2021
Peer-review started: March 4, 2021
First decision: April 4, 2021
Revised: April 8, 2021
Accepted: May 15, 2021
Article in press: May 15, 2021
Published online: August 16, 2021

Core Tip

Core Tip: It was confirmed that the expression of caspase-3 in hepatocellular carcinoma (HCC) complicated by hemorrhagic and necrotic pathological changes decreased and the expression of hypoxia inducible factor 1α (HIF-1α) increased, and these were related to clinicopathological features and prognosis. This study explored the expression characteristics of caspase-3 and HIF-1α in tissues, and their relationship with the biological behavior of HCC complicated by hemorrhage and necrosis. The results will provide guidance for further clinical biological behavior assessments for prognosis prediction.