Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2021; 9(22): 6538-6543
Published online Aug 6, 2021. doi: 10.12998/wjcc.v9.i22.6538
Bystander effect and abscopal effect in recurrent thymic carcinoma treated with carbon-ion radiation therapy: A case report
Yan-Shan Zhang, Yi-He Zhang, Xiao-Jun Li, Ting-Chao Hu, Wei-Zuo Chen, Xin Pan, Hong-Yu Chai, Yan-Cheng Ye
Yan-Shan Zhang, Yi-He Zhang, Xiao-Jun Li, Ting-Chao Hu, Wei-Zuo Chen, Xin Pan, Hong-Yu Chai, Yan-Cheng Ye, Department of Heavy Ion Center, Wuwei Cancer Hospital, Wuwei 733000, Gansu Province, China
Author contributions: Zhang YS and Zhang YH have the same contribution to this article; Zhang YS, Li XJ, Zhang YH and Hu TC designed the experiment; Chen WZ, Pan X and Chai HY drafted the work; Ye YC collected the data; Zhang YS and Li XJ analyzed and interpreted data; Zhang YH and Hu TC wrote the article.
Supported by Key R&D Plan of Science and Technology Program of Gansu Province, China, No. 19YF3FH001.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: Dr. Ye reports grants from Key R&D plan of Science and Technology Program of Gansu Province, China. (NO. 19YF3FH001) during the conduct of the study.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Cheng Ye, PhD, Chief Doctor, Department of Heavy Ion Center, Wuwei Cancer Hospital, No. 31 Sanitary Alley, Haizang Road, Wuwei 733000, Gansu Province, China. zlyyyyc@163.com
Received: April 15, 2021
Peer-review started: April 15, 2021
First decision: May 10, 2021
Revised: May 15, 2021
Accepted: June 17, 2021
Article in press: June 17, 2021
Published online: August 6, 2021
Core Tip

Core Tip: We presented the case of a patient who demonstrated a bystander effect and an abscopal effect following carbon-ion irradiation for recurrent thymic carcinoma. In this report, obvious abscopal and bystander effects after carbon-ion irradiation in a patient was initially presented, and more research is needed to further elucidate the mechanism of bystander and abscopal effects.