Clinical Trials Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2021; 9(22): 6308-6318
Published online Aug 6, 2021. doi: 10.12998/wjcc.v9.i22.6308
Effect of exercise training on left ventricular remodeling in patients with myocardial infarction and possible mechanisms
Meng Cai, Lei Wang, Yan-Long Ren
Meng Cai, Lei Wang, Department of Geriatrics, Beijing Jishuitan Hospital, Beijing 100000, China
Yan-Long Ren, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China
Author contributions: Wang L and Ren YL conceived of the study; Cai M, Wang L, and Ren YL participated in the study and collected the clinical data; Cai M and Wang L performed the statistical analysis and drafted the manuscript; Ren YL revised the manuscript; all authors read and approved the final manuscript.
Supported by Beijing Hospitals Authority Incubating Program, No. PZ2021007; Beijing Hospitals Authority Youth Program, No. QML20200604; and Beijing Municipal Health Commission (No. 17-3) and the Beijing Natural Science Foundation, No. 7184205.
Institutional review board statement: The authors declare that all experiments involving human subjects were designed and performed in compliance with the relevant laws regarding humane care and use of subjects.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to the manuscript.
Data sharing statement: No additional unpublished data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Long Ren, MD, Professor, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Beijing 100029, China. renyanlong@yeah.net
Received: April 8, 2021
Peer-review started: April 8, 2021
First decision: April 28, 2021
Revised: May 12, 2021
Accepted: June 7, 2021
Article in press: June 7, 2021
Published online: August 6, 2021
Processing time: 110 Days and 17.3 Hours
Core Tip

Core Tip: Exercise training under supervision based on home condition in early and recovery stage of acute myocardial infarction can improve exercise cardiopulmonary function and prevent the left ventricular remodeling. And there was no negative effect on left ventricular ejection fraction. Therefore, it may reduce unfavorable remodeling response by decreasing the levels of plasma matrix metallopeptidase 9 (MMP-9) and tissue inhibitor of metalloproteinases 1 (TIMP-1) and adjusting the ratio of MMP-9 to TIMP-1 hereafter.