Case Control Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2021; 9(22): 6244-6253
Published online Aug 6, 2021. doi: 10.12998/wjcc.v9.i22.6244
Risk factors for intussusception in children with Henoch-Schönlein purpura: A case-control study
Qian Zhao, Yan Yang, Song-Wei He, Xin-Tai Wang, Chang Liu
Qian Zhao, Yan Yang, Song-Wei He, Xin-Tai Wang, Chang Liu, Traditional Chinese Medicine Department, National Children's Medical Center, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China
Author contributions: All authors contributed to study conception and design; Zhao Q, Yang Y, He SW, Wang XT, and Liu C performed material preparation and data collection and analysis; Zhao Q wrote the first draft of the manuscript; all authors have revised the manuscript, and read and approved its final version.
Supported by the Beijing Traditional Chinese Medicine Science and Technology Development Fund, No. JJ2018-45; and the Beijing Municipal Natural Science Foundation, No. 7172076 and No. 7212169.
Institutional review board statement: This study conformed to the Helsinki Declaration on Human Beings and was approved by the Beijing Children's Hospital Affiliated to Capital Medical University (No. IEC-C-008-A08-V.05.1).
Informed consent statement: Informed consent was waived.
Conflict-of-interest statement: All authors have nothing to disclose.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Yang, MD, Doctor, Traditional Chinese Medicine Department, National Children’s Medical Center, Beijing Children’s Hospital affiliated to Capital Medical University, No. 56 Nanlishi Road, Xicheng District, Beijing 100045, China. yy2303@sina.com
Received: January 12, 2021
Peer-review started: January 12, 2021
First decision: April 29, 2021
Revised: May 7, 2021
Accepted: June 3, 2021
Article in press: June 3, 2021
Published online: August 6, 2021
Core Tip

Core Tip: Intussusception has an incidence of about 5% in Henoch-Schönlein purpura (HSP), and is a common cause of acute surgical abdomen in the affected children. There is limited research on risk factors for intussusception in children with HSP. Age at onset below 6 years, not receiving glucocorticoid therapy within 72 h of onset of gastrointestinal (GI) symptoms, hematochezia, and increased D-dimer levels are independent risk factors for intussusception in children with HSP and GI involvement.