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World J Clin Cases. Aug 6, 2021; 9(22): 6218-6233
Published online Aug 6, 2021. doi: 10.12998/wjcc.v9.i22.6218
Mesenchymal stem cell-derived exosomes: An emerging therapeutic strategy for normal and chronic wound healing
Qin-Lu Zeng, De-Wu Liu
Qin-Lu Zeng, De-Wu Liu, Burns Institute, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Qin-Lu Zeng, First Clinical Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
Author contributions: Zeng QL contributed to the investigation, data curation, and original draft preparation; Zeng QL and Liu DW contributed to manuscript writing, review, and editing; Liu DW supervised this study.
Supported by National Natural Science Foundation of China, No. 81460293; and Innovation and Entrepreneurship Training Program of Nanchang University, China, No. 20190402184.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: De-Wu Liu, MD, PhD, Chief Doctor, Professor, Burns Institute, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. dewuliu@126.com
Received: February 8, 2021
Peer-review started: February 8, 2021
First decision: March 30, 2021
Revised: April 8, 2021
Accepted: June 22, 2021
Article in press: June 22, 2021
Published online: August 6, 2021
Core Tip

Core Tip: We have mainly sorted out the reported mechanisms by which different mesenchymal stem cells (MSC)-derived exosomes play a promoting role in the hemostatic stage, inflammatory stage, proliferative stage, and remodeling stage of skin wound healing. The clinical prospect of MSC-exosomes as a cell-free therapy, such as the addition of carriers, combination of drugs, combined physical treatment, and development as an immunosuppressive agent, is also summarized.