Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 26, 2021; 9(21): 6073-6080
Published online Jul 26, 2021. doi: 10.12998/wjcc.v9.i21.6073
Neurogenic orthostatic hypotension with Parkinson's disease as a cause of syncope: A case report
Ya Li, Min Wang, Xiang-Lan Liu, Ya-Fei Ren, Wen-Bin Zhang
Ya Li, Min Wang, Xiang-Lan Liu, Wen-Bin Zhang, Department of Cardiovascular Diseases, Sir Run Run Shaw Hospital, College of Medicine of Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Ya-Fei Ren, Department of Rehabilitation Medicine, Qilu Institute of Technology, Jinan 250200, Shandong Province, China
Author contributions: Li Y and Ren YF reviewed the literature and contributed to manuscript drafting; Wang M and Liu XL were the patient’s cardiologists; Zhang WB was responsible for the revision of the manuscript for important intellectual content; all authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Wen-Bin Zhang, PhD, Associate Chief Physician, Department of Cardiovascular Diseases, Sir Run Run Shaw Hospital, College of Medicine of Zhejiang University, No. 3 Qinchundong Road, Hangzhou 310016, Zhejiang Province, China.
Received: March 18, 2021
Peer-review started: March 18, 2021
First decision: April 23, 2021
Revised: May 6, 2021
Accepted: May 15, 2021
Article in press: May 15, 2021
Published online: July 26, 2021
Core Tip

Core Tip: Syncope presents with diagnostic challenges and is associated with high healthcare costs. For syncope caused by a change in position, neurogenic orthostatic hypotension (nOH) should be considered to reduce missed diagnosis and misdiagnosis. Paying attention to comorbidities, such as Parkinson's disease and diabetes which could cause can autonomic dysfunction, also helps in the diagnosis of the cause of syncope. Ambulatory blood pressure monitoring can assist in diagnosing nOH. It is very challenging for clinicians to manage patients with nOH and supine hypertension. Increasing physical activity and reducing the amount of time in bed are still the primary management methods.