Published online Jul 26, 2021. doi: 10.12998/wjcc.v9.i21.5794
Peer-review started: March 12, 2021
First decision: April 13, 2021
Revised: April 24, 2021
Accepted: May 26, 2021
Article in press: May 26, 2021
Published online: July 26, 2021
Core Tip: Prevalence of hyperlipidemic acute pancreatitis has greatly increased and has become the most common cause of acute pancreatitis not due to gallstones or alcohol. Although therapeutic plasmapheresis has emerged as an effective modality in rapidly reducing serum triglyceride levels and has been used for hyperlipidemic acute pancreatitis clinically, the exact role of therapeutic plasmapheresis in the disease course is unclear and remains poorly evaluated. We herein outline the current evidence and discuss the future research directions.